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• W2180072122 endingPage "e0142407" @default.
• W2180072122 startingPage "e0142407" @default.
• W2180072122 abstract "Switching of bacterial flagellar rotation is caused by large domain movements of the FliG protein triggered by binding of the signal protein CheY to FliM. FliG and FliM form adjacent multi-subunit arrays within the basal body C-ring. The movements alter the interaction of the FliG C-terminal (FliGC) torque helix with the stator complexes. Atomic models based on the Salmonella entrovar C-ring electron microscopy reconstruction have implications for switching, but lack consensus on the relative locations of the FliG armadillo (ARM) domains (amino-terminal (FliGN), middle (FliGM) and FliGC) as well as changes during chemotaxis. The generality of the Salmonella model is challenged by the variation in motor morphology and response between species. We studied coevolved residue mutations to determine the unifying elements of switch architecture. Residue interactions, measured by their coevolution, were formalized as a network, guided by structural data. Our measurements reveal a common design with dedicated switch and motor modules. The FliM middle domain (FliMM) has extensive connectivity most simply explained by conserved intra and inter-subunit contacts. In contrast, FliG has patchy, complex architecture. Conserved structural motifs form interacting nodes in the coevolution network that wire FliMM to the FliGC C-terminal, four-helix motor module (C3-6). FliG C3-6 coevolution is organized around the torque helix, differently from other ARM domains. The nodes form separated, surface-proximal patches that are targeted by deleterious mutations as in other allosteric systems. The dominant node is formed by the EHPQ motif at the FliMMFliGM contact interface and adjacent helix residues at a central location within FliGM. The node interacts with nodes in the N-terminal FliGc α-helix triad (ARM-C) and FliGN. ARM-C, separated from C3-6 by the MFVF motif, has poor intra-network connectivity consistent with its variable orientation revealed by structural data. ARM-C could be the convertor element that provides mechanistic and species diversity." @default.
• W2180072122 created "2016-06-24" @default.
• W2180072122 creator A5053576534 @default.
• W2180072122 creator A5063875453 @default.
• W2180072122 creator A5065037104 @default.
• W2180072122 creator A5079015407 @default.
• W2180072122 date "2015-11-12" @default.
• W2180072122 modified "2023-10-17" @default.
• W2180072122 title "Coevolved Mutations Reveal Distinct Architectures for Two Core Proteins in the Bacterial Flagellar Motor" @default.
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• W2180072122 doi "https://doi.org/10.1371/journal.pone.0142407" @default.
• W2180072122 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4642947" @default.
• W2180072122 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26561852" @default.
• W2180072122 hasPublicationYear "2015" @default.
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