Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180147111> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2180147111 endingPage "119" @default.
- W2180147111 startingPage "115" @default.
- W2180147111 abstract "Context: Adverse reactions to intravenous (IV) acetylcysteine treatment in paracetamol overdose, are common. Previous studies suggest the incidence and severity of non-allergic anaphylactic reactions (NAARs) are influenced by the rate of acetylcysteine infusion. Objective: We compared the incidence of adverse drug events of a two-bag IV acetylcysteine regimen with that of the traditional three-bag regimen. Materials and methods: This was a retrospective analysis of patients presenting with paracetamol overdose requiring treatment with acetylcysteine to three emergency departments. We prospectively identified all presentations where IV acetylcysteine was administered using a 20 h, two-bag regimen (200 mg/kg over 4 h followed by 100 mg/kg over 16 h) from February 2014 to June 2015. We compared this to an historical cohort treated with the 21 h three-bag IV regimen (150 mg/kg over 1 h, 50 mg/kg over 4 h and 100 mg/kg over 16 h) from October 2009 to October 2013. Medical and nursing notes were searched retrospectively for entries suggesting the presence of an adverse reaction. The primary outcome was incidence of NAARs and gastrointestinal reactions in each group. Results: 389 presentations were treated with the three-bag regimen and 210 presentations received the two-bag regimen. NAARs were recorded more commonly with the three-bag acetylcysteine regimen than the two-bag regimen (10% vs 4.3%, p = 0.02, OR 2.5, 95% CI 1.1–5.8). There was no difference in reports of gastrointestinal reactions between cohorts (three-bag 39% vs two-bag 41%, p = 0.38, OR 1.17 95% CI (0.83–1.65)). Discussion: The incidence of NAARs was significantly reduced by combining the first two bags of the traditional three-bag regimen and infusing these over 4 h at 50 mg/kg/hr. Simplifying the administration of acetylcysteine may have other benefits such as better utilisation of nursing time and reduced infusion administration errors. Conclusions: A two-bag 20 h acetylcysteine regimen was well tolerated and resulted in significantly fewer and milder NAARs than the standard three-bag regimen." @default.
- W2180147111 created "2016-06-24" @default.
- W2180147111 creator A5014555323 @default.
- W2180147111 creator A5042349056 @default.
- W2180147111 date "2015-11-23" @default.
- W2180147111 modified "2023-09-29" @default.
- W2180147111 title "Simplification of the standard three-bag intravenous acetylcysteine regimen for paracetamol poisoning results in a lower incidence of adverse drug reactions" @default.
- W2180147111 cites W15769779 @default.
- W2180147111 cites W1991729084 @default.
- W2180147111 cites W2012708909 @default.
- W2180147111 cites W2014851393 @default.
- W2180147111 cites W2021144590 @default.
- W2180147111 cites W2077386507 @default.
- W2180147111 cites W2106785595 @default.
- W2180147111 cites W2118609188 @default.
- W2180147111 cites W2125652802 @default.
- W2180147111 cites W2139908913 @default.
- W2180147111 cites W2144336037 @default.
- W2180147111 cites W2150256003 @default.
- W2180147111 cites W2171720135 @default.
- W2180147111 cites W2768361598 @default.
- W2180147111 cites W4211079886 @default.
- W2180147111 doi "https://doi.org/10.3109/15563650.2015.1115055" @default.
- W2180147111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26594846" @default.
- W2180147111 hasPublicationYear "2015" @default.
- W2180147111 type Work @default.
- W2180147111 sameAs 2180147111 @default.
- W2180147111 citedByCount "53" @default.
- W2180147111 countsByYear W21801471112015 @default.
- W2180147111 countsByYear W21801471112016 @default.
- W2180147111 countsByYear W21801471112017 @default.
- W2180147111 countsByYear W21801471112018 @default.
- W2180147111 countsByYear W21801471112019 @default.
- W2180147111 countsByYear W21801471112020 @default.
- W2180147111 countsByYear W21801471112021 @default.
- W2180147111 countsByYear W21801471112022 @default.
- W2180147111 countsByYear W21801471112023 @default.
- W2180147111 crossrefType "journal-article" @default.
- W2180147111 hasAuthorship W2180147111A5014555323 @default.
- W2180147111 hasAuthorship W2180147111A5042349056 @default.
- W2180147111 hasConcept C120665830 @default.
- W2180147111 hasConcept C121332964 @default.
- W2180147111 hasConcept C126322002 @default.
- W2180147111 hasConcept C141071460 @default.
- W2180147111 hasConcept C151730666 @default.
- W2180147111 hasConcept C185592680 @default.
- W2180147111 hasConcept C197934379 @default.
- W2180147111 hasConcept C2777847592 @default.
- W2180147111 hasConcept C2778004101 @default.
- W2180147111 hasConcept C2779343474 @default.
- W2180147111 hasConcept C2781413609 @default.
- W2180147111 hasConcept C42219234 @default.
- W2180147111 hasConcept C55493867 @default.
- W2180147111 hasConcept C61511704 @default.
- W2180147111 hasConcept C71924100 @default.
- W2180147111 hasConcept C86803240 @default.
- W2180147111 hasConceptScore W2180147111C120665830 @default.
- W2180147111 hasConceptScore W2180147111C121332964 @default.
- W2180147111 hasConceptScore W2180147111C126322002 @default.
- W2180147111 hasConceptScore W2180147111C141071460 @default.
- W2180147111 hasConceptScore W2180147111C151730666 @default.
- W2180147111 hasConceptScore W2180147111C185592680 @default.
- W2180147111 hasConceptScore W2180147111C197934379 @default.
- W2180147111 hasConceptScore W2180147111C2777847592 @default.
- W2180147111 hasConceptScore W2180147111C2778004101 @default.
- W2180147111 hasConceptScore W2180147111C2779343474 @default.
- W2180147111 hasConceptScore W2180147111C2781413609 @default.
- W2180147111 hasConceptScore W2180147111C42219234 @default.
- W2180147111 hasConceptScore W2180147111C55493867 @default.
- W2180147111 hasConceptScore W2180147111C61511704 @default.
- W2180147111 hasConceptScore W2180147111C71924100 @default.
- W2180147111 hasConceptScore W2180147111C86803240 @default.
- W2180147111 hasIssue "2" @default.
- W2180147111 hasLocation W21801471111 @default.
- W2180147111 hasLocation W21801471112 @default.
- W2180147111 hasOpenAccess W2180147111 @default.
- W2180147111 hasPrimaryLocation W21801471111 @default.
- W2180147111 hasRelatedWork W1586374228 @default.
- W2180147111 hasRelatedWork W2003938723 @default.
- W2180147111 hasRelatedWork W2047967234 @default.
- W2180147111 hasRelatedWork W2118496982 @default.
- W2180147111 hasRelatedWork W2275480158 @default.
- W2180147111 hasRelatedWork W2364998975 @default.
- W2180147111 hasRelatedWork W2369162477 @default.
- W2180147111 hasRelatedWork W2439875401 @default.
- W2180147111 hasRelatedWork W4238867864 @default.
- W2180147111 hasRelatedWork W2525756941 @default.
- W2180147111 hasVolume "54" @default.
- W2180147111 isParatext "false" @default.
- W2180147111 isRetracted "false" @default.
- W2180147111 magId "2180147111" @default.
- W2180147111 workType "article" @default.