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- W2180164162 abstract "Evolutionarily conserved signalling intermediate in Toll pathways(ECSIT) was identified orginally as a TNF receptor associated factor6 (TRAF6) interacting partner. The murine homolog mECSIT hasbeen shown to be involved in NFκB, MAPK, BMP and mitochondrialsignalling. To date there is no work published on the humanhomolog, hECSIT. In this thesis, I present data indicating that hECSITis involved in NFκB, BMP and MAPK signalling. There is a strikingdifference in the role of hECSIT and mECSIT in the activation ofinflammatory transcription factors NFκB, ELK-1 and AP-1; withmECSIT augmenting their activation and hECSIT having an inhibitoryrole. In addition I demonstrate that hECSIT specifically targets thep42/44 branch of MAPK signalling. Suppression of endogenoushECSIT results in increased basal and proinflammatory inducedphosphorylation of p42/44 but not JNK or p38. Thus, hECSITsignalling represents a novel means of regulating p42/44 and itsdownstream targets." @default.
- W2180164162 created "2016-06-24" @default.
- W2180164162 creator A5001278951 @default.
- W2180164162 date "2012-01-01" @default.
- W2180164162 modified "2023-09-27" @default.
- W2180164162 title "Characterisation of the role ofhuman Evolutionary ConservedSignalling Intermediate in Toll(ECSIT) in Mitogen Activated ProteinKinase (MAPK) signalling" @default.
- W2180164162 hasPublicationYear "2012" @default.
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