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• W2180237189 abstract "Background: Clevidipine is an ester-containing antihypertensive agent that undergoes rapid hydrolysis in blood. A reliable stabilizer cocktail containing citric acid and ascorbic acid was established and the LC–MS/MS method was validated for simultaneous determination of clevidipine and its major metabolite in beagle dog whole blood. Results: The stabilizer could nearly completely inhibit the esterase activity. Both analytes were extracted from whole blood by toluene and detected by MS/MS in positive ESI mode. The linearity range was 0.1–100.0 ng/ml for clevidipine and 1.0–1000.0 ng/ml for the primary metabolite. Conclusion: The stabilizer cocktail was able to effectively suppress the activity of esterase in blood. The method was successfully applied to a PK study of clevidipine in beagle dogs." @default.
• W2180237189 created "2016-06-24" @default.
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• W2180237189 date "2015-07-01" @default.
• W2180237189 modified "2023-09-22" @default.
• W2180237189 title "Screening of stabilizers for LC–MS/MS analysis of clevidipine and its primary metabolite in dog whole blood" @default.
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• W2180237189 doi "https://doi.org/10.4155/bio.15.74" @default.
• W2180237189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26168253" @default.
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