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- W2180283457 endingPage "167" @default.
- W2180283457 startingPage "135" @default.
- W2180283457 abstract "The key molecular event in the pathogenesis of prion diseases is the conformational conversion of a cellular prion protein, PrP(C), into a misfolded form, PrP(Sc). In contrast to PrP(C) that is monomeric and α-helical, PrP(Sc) is oligomeric in nature and rich in β-sheet structure. According to the protein-only model, PrP(Sc) itself represents the infectious prion agent responsible for transmissibility of prion disorders. While this model is supported by rapidly growing experimental data, detailed mechanistic and structural aspects of prion protein conversion remain enigmatic. In this chapter we describe recent advances in understanding biophysical and biochemical aspects of prion diseases, with a special focus on structural underpinnings of prion protein conversion, the structural basis of prion strains, and generation of prion infectivity in vitro from bacterially-expressed recombinant PrP." @default.
- W2180283457 created "2016-06-24" @default.
- W2180283457 creator A5039607513 @default.
- W2180283457 creator A5063200184 @default.
- W2180283457 date "2011-01-01" @default.
- W2180283457 modified "2023-10-10" @default.
- W2180283457 title "Prion Protein and Its Conformational Conversion: A Structural Perspective" @default.
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