FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180357773> ?p ?o ?g. }

• W2180357773 abstract "Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in these cells. Perforin-2 knockout mice are unable to control the systemic dissemination of methicillin-resistant Staphylococcus aureus (MRSA) or Salmonella typhimurium and perish shortly after epicutaneous or orogastric infection respectively. In contrast, Perforin-2-sufficient littermates clear the infection. Perforin-2 is a transmembrane protein of cytosolic vesicles -derived from multiple organelles- that translocate to and fuse with bacterium containing vesicles. Subsequently, Perforin-2 polymerizes and forms large clusters of 100 Å pores in the bacterial surface with Perforin-2 cleavage products present in bacteria. Perforin-2 is also required for the bactericidal activity of reactive oxygen and nitrogen species and hydrolytic enzymes. Perforin-2 constitutes a novel and apparently essential bactericidal effector molecule of the innate immune system." @default.
• W2180357773 created "2016-06-24" @default.
• W2180357773 creator A5005631628 @default.
• W2180357773 creator A5022056720 @default.
• W2180357773 creator A5024398568 @default.
• W2180357773 creator A5026441848 @default.
• W2180357773 creator A5030633948 @default.
• W2180357773 creator A5036159778 @default.
• W2180357773 creator A5039963706 @default.
• W2180357773 creator A5045611437 @default.
• W2180357773 creator A5055229535 @default.
• W2180357773 creator A5055305750 @default.
• W2180357773 creator A5064151687 @default.
• W2180357773 creator A5065185002 @default.
• W2180357773 creator A5068471387 @default.
• W2180357773 creator A5070135491 @default.
• W2180357773 creator A5070706221 @default.
• W2180357773 creator A5080546814 @default.
• W2180357773 creator A5084368638 @default.
• W2180357773 creator A5088125558 @default.
• W2180357773 date "2015-09-24" @default.
• W2180357773 modified "2023-10-18" @default.
• W2180357773 title "Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria" @default.
• W2180357773 cites W1518956061 @default.
• W2180357773 cites W1527195406 @default.
• W2180357773 cites W1579261512 @default.
• W2180357773 cites W1818624993 @default.
• W2180357773 cites W1821971821 @default.
• W2180357773 cites W1972222351 @default.
• W2180357773 cites W1972348350 @default.
• W2180357773 cites W1977463246 @default.
• W2180357773 cites W1980273151 @default.
• W2180357773 cites W1984564731 @default.
• W2180357773 cites W1988779160 @default.
• W2180357773 cites W1989353671 @default.
• W2180357773 cites W1989482042 @default.
• W2180357773 cites W1990621187 @default.
• W2180357773 cites W1997702982 @default.
• W2180357773 cites W2000623722 @default.
• W2180357773 cites W2004094671 @default.
• W2180357773 cites W2005474858 @default.
• W2180357773 cites W2012417221 @default.
• W2180357773 cites W2013145745 @default.
• W2180357773 cites W2013345905 @default.
• W2180357773 cites W2018325317 @default.
• W2180357773 cites W2022093637 @default.
• W2180357773 cites W2023822923 @default.
• W2180357773 cites W2030513906 @default.
• W2180357773 cites W2031538453 @default.
• W2180357773 cites W2033672795 @default.
• W2180357773 cites W2033848761 @default.
• W2180357773 cites W2038153474 @default.
• W2180357773 cites W2039478605 @default.
• W2180357773 cites W2052230676 @default.
• W2180357773 cites W2056624519 @default.
• W2180357773 cites W2059931536 @default.
• W2180357773 cites W2061278221 @default.
• W2180357773 cites W2061909518 @default.
• W2180357773 cites W2063420993 @default.
• W2180357773 cites W2068851350 @default.
• W2180357773 cites W2069351131 @default.
• W2180357773 cites W2070505242 @default.
• W2180357773 cites W2074481254 @default.
• W2180357773 cites W2075400586 @default.
• W2180357773 cites W2078466641 @default.
• W2180357773 cites W2081756009 @default.
• W2180357773 cites W2084542841 @default.
• W2180357773 cites W2085551318 @default.
• W2180357773 cites W2088344925 @default.
• W2180357773 cites W2089701444 @default.
• W2180357773 cites W2090603339 @default.
• W2180357773 cites W2093158584 @default.
• W2180357773 cites W2094375702 @default.
• W2180357773 cites W2094532029 @default.
• W2180357773 cites W2096212458 @default.
• W2180357773 cites W2102601193 @default.
• W2180357773 cites W2107941964 @default.
• W2180357773 cites W2116137883 @default.
• W2180357773 cites W2118932941 @default.
• W2180357773 cites W2120420351 @default.
• W2180357773 cites W2124519481 @default.
• W2180357773 cites W2130786876 @default.
• W2180357773 cites W2136722399 @default.
• W2180357773 cites W2140813750 @default.
• W2180357773 cites W2141391869 @default.
• W2180357773 cites W2145189896 @default.
• W2180357773 cites W2145386430 @default.
• W2180357773 cites W2146771855 @default.
• W2180357773 cites W2151917132 @default.
• W2180357773 cites W2152783224 @default.
• W2180357773 cites W2156071476 @default.
• W2180357773 cites W2156135402 @default.
• W2180357773 cites W2156373483 @default.
• W2180357773 cites W2162493943 @default.
• W2180357773 cites W2171148103 @default.
• W2180357773 cites W2285587112 @default.
• W2180357773 cites W4244081605 @default.
• W2180357773 cites W4251406788 @default.
• W2180357773 doi "https://doi.org/10.7554/elife.06508" @default.
• W2180357773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4626811" @default.

• next