Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180413537> ?p ?o ?g. }
- W2180413537 endingPage "333" @default.
- W2180413537 startingPage "324" @default.
- W2180413537 abstract "At fast-transmitting presynaptic terminals Ca2+ enter through voltage gated calcium channels (CaVs) and bind to a synaptic vesicle (SV) -associated calcium sensor (SV-sensor) to gate fusion and discharge. An open CaV generates a high-concentration plume, or nanodomain of Ca2+ that dissipates precipitously with distance from the pore. At most fast synapses, such as the frog neuromuscular junction (NMJ), the SV sensors are located sufficiently close to individual CaVs to be gated by single nanodomains. However, at others, such as the mature rodent calyx of Held (calyx of Held), the physiology is more complex with evidence that CaVs that are both close and distant from the SV sensor and it is argued that release is gated primarily by the overlapping Ca2+ nanodomains from many CaVs. We devised a 'graphic modeling' method to sum Ca2+ from individual CaVs located at varying distances from the SV-sensor to determine the SV release probability and also the fraction of that probability that can be attributed to single domain gating. This method was applied first to simplified, low and high CaV density model release sites and then to published data on the contrasting frog NMJ and the rodent calyx of Held native synapses. We report 3 main predictions: the SV-sensor is positioned very close to the point at which the SV fuses with the membrane; single domain-release gating predominates even at synapses where the SV abuts a large cluster of CaVs, and even relatively remote CaVs can contribute significantly to single domain-based gating." @default.
- W2180413537 created "2016-06-24" @default.
- W2180413537 creator A5061241655 @default.
- W2180413537 date "2015-09-03" @default.
- W2180413537 modified "2023-09-26" @default.
- W2180413537 title "Single calcium channel domain gating of synaptic vesicle fusion at fast synapses; analysis by graphic modeling" @default.
- W2180413537 cites W1499946971 @default.
- W2180413537 cites W1520756199 @default.
- W2180413537 cites W1559861960 @default.
- W2180413537 cites W1560932778 @default.
- W2180413537 cites W1642181682 @default.
- W2180413537 cites W1670760110 @default.
- W2180413537 cites W1843809171 @default.
- W2180413537 cites W184718354 @default.
- W2180413537 cites W1964596341 @default.
- W2180413537 cites W1964731537 @default.
- W2180413537 cites W1967445686 @default.
- W2180413537 cites W1968669554 @default.
- W2180413537 cites W1968919485 @default.
- W2180413537 cites W1969308562 @default.
- W2180413537 cites W1970200112 @default.
- W2180413537 cites W1973199077 @default.
- W2180413537 cites W1973795772 @default.
- W2180413537 cites W1978630448 @default.
- W2180413537 cites W1978934890 @default.
- W2180413537 cites W1979381976 @default.
- W2180413537 cites W1980376542 @default.
- W2180413537 cites W1982212676 @default.
- W2180413537 cites W1983681582 @default.
- W2180413537 cites W1983820222 @default.
- W2180413537 cites W1987303476 @default.
- W2180413537 cites W1991641421 @default.
- W2180413537 cites W1993656822 @default.
- W2180413537 cites W1994123659 @default.
- W2180413537 cites W1996618398 @default.
- W2180413537 cites W2000109425 @default.
- W2180413537 cites W2002897495 @default.
- W2180413537 cites W2004160272 @default.
- W2180413537 cites W2005686453 @default.
- W2180413537 cites W2011057572 @default.
- W2180413537 cites W2011885136 @default.
- W2180413537 cites W2027891453 @default.
- W2180413537 cites W2028789389 @default.
- W2180413537 cites W2029308813 @default.
- W2180413537 cites W2030034627 @default.
- W2180413537 cites W2030419485 @default.
- W2180413537 cites W2030428080 @default.
- W2180413537 cites W2033866317 @default.
- W2180413537 cites W2035018673 @default.
- W2180413537 cites W2036960879 @default.
- W2180413537 cites W2040618621 @default.
- W2180413537 cites W2044167411 @default.
- W2180413537 cites W2044420805 @default.
- W2180413537 cites W2047397502 @default.
- W2180413537 cites W2048410066 @default.
- W2180413537 cites W2051380496 @default.
- W2180413537 cites W2052495746 @default.
- W2180413537 cites W2052960022 @default.
- W2180413537 cites W2057218945 @default.
- W2180413537 cites W2057664279 @default.
- W2180413537 cites W2057759105 @default.
- W2180413537 cites W2062017949 @default.
- W2180413537 cites W2071019848 @default.
- W2180413537 cites W2072747721 @default.
- W2180413537 cites W2075183645 @default.
- W2180413537 cites W2078039225 @default.
- W2180413537 cites W2078039971 @default.
- W2180413537 cites W2085537082 @default.
- W2180413537 cites W2087758815 @default.
- W2180413537 cites W2090662268 @default.
- W2180413537 cites W2091694654 @default.
- W2180413537 cites W2093441174 @default.
- W2180413537 cites W2094314734 @default.
- W2180413537 cites W2094807062 @default.
- W2180413537 cites W2094930349 @default.
- W2180413537 cites W2101691189 @default.
- W2180413537 cites W2101766473 @default.
- W2180413537 cites W2110507626 @default.
- W2180413537 cites W2113671810 @default.
- W2180413537 cites W2119063345 @default.
- W2180413537 cites W2122383890 @default.
- W2180413537 cites W2123091486 @default.
- W2180413537 cites W2128967907 @default.
- W2180413537 cites W2134731864 @default.
- W2180413537 cites W2138903675 @default.
- W2180413537 cites W2142080729 @default.
- W2180413537 cites W2146381819 @default.
- W2180413537 cites W2152712045 @default.
- W2180413537 cites W2153963764 @default.
- W2180413537 cites W2157572330 @default.
- W2180413537 cites W2161785510 @default.
- W2180413537 cites W2417057034 @default.
- W2180413537 cites W33448186 @default.
- W2180413537 cites W64980994 @default.
- W2180413537 doi "https://doi.org/10.1080/19336950.2015.1098793" @default.
- W2180413537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4826128" @default.
- W2180413537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26457441" @default.
- W2180413537 hasPublicationYear "2015" @default.