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- W2180437487 abstract "Neurofibromatosis type 2 (NF2)-associated vestibular schwannomas have variable size at presentation which presents a unique challenge in NF2 patient management. Therefore, we investigated the molecular signature characteristic of the differences in size for improved individualized precise therapy.RNA expression analysis was performed on 15 small and 27 large NF2-associated vestibular schwannoma tumors using a microarray analyzing over 47,000 transcripts.A signature of 11 genes was found to be correlated with NF2 tumor size.We have identified the genetic hallmark that differentiates large NF2-associated tumors from smaller tumors. This is the first time that these genes have been shown to be the hallmark for NF2 tumor size." @default.
- W2180437487 created "2016-06-24" @default.
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- W2180437487 date "2015-06-01" @default.
- W2180437487 modified "2023-10-02" @default.
- W2180437487 title "Schwannomas exhibit distinct size-dependent gene-expression patterns" @default.
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- W2180437487 doi "https://doi.org/10.2217/fon.15.72" @default.
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