FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180454723> ?p ?o ?g. }

• W2180454723 endingPage "G692" @default.
• W2180454723 startingPage "G682" @default.
• W2180454723 abstract "We investigated the long-term effect of metformin treatment on blood pressure, insulin sensitivity, and vascular responses to insulin in conscious spontaneously hypertensive rats (SHR). The rats were instrumented with intravascular catheters and pulsed Doppler flow probes to measure blood pressure, heart rate, and blood flow. Insulin sensitivity was assessed by the euglycemic hyperinsulinemic clamp technique. Two groups of SHR received metformin (100 or 300 mg x kg(-1) x day(-1)) for 3 wk while another group of SHR and a group of Wistar Kyoto (WKY) rats were left untreated. We found that vasodilation of skeletal muscle and renal vasculatures by insulin is impaired in SHR. Moreover, a reduced insulin sensitivity was detected in vivo and in vitro in isolated soleus and extensor digitorum longus muscles from SHR compared with WKY rats. Three weeks of treatment with metformin improves the whole-body insulin-mediated glucose disposal in SHR but has no blood pressure-lowering effect and no influence on vascular responses to insulin (4 mU x kg(-1) x min(-1)). An improvement in insulin-mediated glucose transport activity was detected in isolated muscles from metformin-treated SHR, but in the absence of insulin no changes in basal glucose transport activity were observed. It is suggested that part of the beneficial effect of metformin on insulin resistance results from a potentiation of the hormone-stimulating effect on glucose transport in peripheral tissues (mainly skeletal muscle). The results argue against a significant antihypertensive or vascular effect of metformin in SHR." @default.
• W2180454723 created "2016-06-24" @default.
• W2180454723 creator A5007768979 @default.
• W2180454723 creator A5026061585 @default.
• W2180454723 creator A5033927550 @default.
• W2180454723 creator A5064221970 @default.
• W2180454723 creator A5081112788 @default.
• W2180454723 creator A5091555131 @default.
• W2180454723 date "2000-05-01" @default.
• W2180454723 modified "2023-10-17" @default.
• W2180454723 title "Effect of metformin on the vascular and glucose metabolic actions of insulin in hypertensive rats" @default.
• W2180454723 cites W197348414 @default.
• W2180454723 cites W1977491852 @default.
• W2180454723 cites W1979110885 @default.
• W2180454723 cites W1993830514 @default.
• W2180454723 cites W1997037157 @default.
• W2180454723 cites W2002815346 @default.
• W2180454723 cites W2016264464 @default.
• W2180454723 cites W2018568241 @default.
• W2180454723 cites W2020823336 @default.
• W2180454723 cites W2021392889 @default.
• W2180454723 cites W2031058311 @default.
• W2180454723 cites W2036506694 @default.
• W2180454723 cites W2036907401 @default.
• W2180454723 cites W2039851346 @default.
• W2180454723 cites W2064148575 @default.
• W2180454723 cites W2070771890 @default.
• W2180454723 cites W2091510428 @default.
• W2180454723 cites W2104847030 @default.
• W2180454723 cites W2111205039 @default.
• W2180454723 cites W2136912103 @default.
• W2180454723 cites W2141659719 @default.
• W2180454723 cites W2143238233 @default.
• W2180454723 cites W2151763612 @default.
• W2180454723 cites W2164884154 @default.
• W2180454723 cites W2253017846 @default.
• W2180454723 cites W2269425308 @default.
• W2180454723 cites W2280048211 @default.
• W2180454723 cites W2340426773 @default.
• W2180454723 cites W2344656836 @default.
• W2180454723 doi "https://doi.org/10.1152/ajpgi.2000.278.5.g682" @default.
• W2180454723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10801260" @default.
• W2180454723 hasPublicationYear "2000" @default.
• W2180454723 type Work @default.
• W2180454723 sameAs 2180454723 @default.
• W2180454723 citedByCount "19" @default.
• W2180454723 countsByYear W21804547232012 @default.
• W2180454723 countsByYear W21804547232013 @default.
• W2180454723 countsByYear W21804547232014 @default.
• W2180454723 countsByYear W21804547232017 @default.
• W2180454723 countsByYear W21804547232021 @default.
• W2180454723 countsByYear W21804547232023 @default.
• W2180454723 crossrefType "journal-article" @default.
• W2180454723 hasAuthorship W2180454723A5007768979 @default.
• W2180454723 hasAuthorship W2180454723A5026061585 @default.
• W2180454723 hasAuthorship W2180454723A5033927550 @default.
• W2180454723 hasAuthorship W2180454723A5064221970 @default.
• W2180454723 hasAuthorship W2180454723A5081112788 @default.
• W2180454723 hasAuthorship W2180454723A5091555131 @default.
• W2180454723 hasConcept C120770815 @default.
• W2180454723 hasConcept C126322002 @default.
• W2180454723 hasConcept C134018914 @default.
• W2180454723 hasConcept C2777391703 @default.
• W2180454723 hasConcept C2777866211 @default.
• W2180454723 hasConcept C2778024521 @default.
• W2180454723 hasConcept C2779306644 @default.
• W2180454723 hasConcept C2779959927 @default.
• W2180454723 hasConcept C2780323712 @default.
• W2180454723 hasConcept C71924100 @default.
• W2180454723 hasConcept C84393581 @default.
• W2180454723 hasConceptScore W2180454723C120770815 @default.
• W2180454723 hasConceptScore W2180454723C126322002 @default.
• W2180454723 hasConceptScore W2180454723C134018914 @default.
• W2180454723 hasConceptScore W2180454723C2777391703 @default.
• W2180454723 hasConceptScore W2180454723C2777866211 @default.
• W2180454723 hasConceptScore W2180454723C2778024521 @default.
• W2180454723 hasConceptScore W2180454723C2779306644 @default.
• W2180454723 hasConceptScore W2180454723C2779959927 @default.
• W2180454723 hasConceptScore W2180454723C2780323712 @default.
• W2180454723 hasConceptScore W2180454723C71924100 @default.
• W2180454723 hasConceptScore W2180454723C84393581 @default.
• W2180454723 hasIssue "5" @default.
• W2180454723 hasLocation W21804547231 @default.
• W2180454723 hasLocation W21804547232 @default.
• W2180454723 hasOpenAccess W2180454723 @default.
• W2180454723 hasPrimaryLocation W21804547231 @default.
• W2180454723 hasRelatedWork W138803513 @default.
• W2180454723 hasRelatedWork W1966225706 @default.
• W2180454723 hasRelatedWork W2006513370 @default.
• W2180454723 hasRelatedWork W2047134324 @default.
• W2180454723 hasRelatedWork W2066345847 @default.
• W2180454723 hasRelatedWork W2077141017 @default.
• W2180454723 hasRelatedWork W2082140668 @default.
• W2180454723 hasRelatedWork W2171960002 @default.
• W2180454723 hasRelatedWork W2406269388 @default.
• W2180454723 hasRelatedWork W2744240433 @default.
• W2180454723 hasVolume "278" @default.
• W2180454723 isParatext "false" @default.

• next