Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180473257> ?p ?o ?g. }
- W2180473257 endingPage "187" @default.
- W2180473257 startingPage "179" @default.
- W2180473257 abstract "Serum amyloid P conpoent (SAP), a member of the pentraxin family, interact with pathogens and cell debris to promote their removal by macrophages and neutrophils and is co-localized with atherosclerotic plaques in patients. However, the exact mechanism of SAP in atherogenesis is still unclear. We investigated whether SAP influence macrophage recruitment and foam cell formation and ultimately affect atherosclerotic progression.we generated apoE(-/-); SAP(-/-) (DKO) mice and fed them western diet for 4 and 8 weeks to characterize atherosclerosis development.SAP deficiency effectively reduced plaque size both in the aorta (p = 0.0006 for 4 wks; p = 0.0001 for 8 wks) and the aortic root (p = 0.0061 for 4 wks; p = 0.0079 for 8wks) compared with apoE(-/-) mice. Meanwhile, SAP deficiency inhibited oxLDL-induced foam cell formation (p = 0.0004) compared with apoE(-/-) mice and SAP treatment increases oxLDL-induced foam cell formation (p = 0.002) in RAW cells. Besides, SAP deficiency reduced macrophages recruitment (p = 0.035) in vivo and in vitro (p = 0.026). Furthermore, SAP treatment enhanced CD36 (p = 0.007) and FcγRI (p = 0.031) expression induced by oxLDL through upregulating JNK and p38 MAPK phosphorylation whereas specific JNK1/2 inhibitor reduced CD36 (p = 0.0005) and FcγRI (P = 0.0007) expression in RAW cell. SAP deficiency also significantly decreased the expression of M1 and M2 macrophage markers and inflammatory cytokines in oxLDL-induced macrophages.SAP deficiency mitigated foam cell formation and atherosclerotic development in apoE(-/-) mice, due to reduction in macrophages recruitment, polarization and pro-inflammatory cytokines and inhibition the CD36/FcγR-dependent signaling pathway." @default.
- W2180473257 created "2016-06-24" @default.
- W2180473257 creator A5008421418 @default.
- W2180473257 creator A5011388364 @default.
- W2180473257 creator A5014335750 @default.
- W2180473257 creator A5016569030 @default.
- W2180473257 creator A5019685555 @default.
- W2180473257 creator A5025461838 @default.
- W2180473257 creator A5028351634 @default.
- W2180473257 creator A5036576116 @default.
- W2180473257 creator A5038449262 @default.
- W2180473257 creator A5050519821 @default.
- W2180473257 creator A5060825242 @default.
- W2180473257 creator A5086473866 @default.
- W2180473257 date "2016-01-01" @default.
- W2180473257 modified "2023-10-15" @default.
- W2180473257 title "SAP deficiency mitigated atherosclerotic lesions in ApoE−/− mice" @default.
- W2180473257 cites W1515006217 @default.
- W2180473257 cites W1597614503 @default.
- W2180473257 cites W1975454948 @default.
- W2180473257 cites W1975809414 @default.
- W2180473257 cites W1975905715 @default.
- W2180473257 cites W1976818997 @default.
- W2180473257 cites W1980763172 @default.
- W2180473257 cites W1981000063 @default.
- W2180473257 cites W1983961544 @default.
- W2180473257 cites W1985801255 @default.
- W2180473257 cites W1988995464 @default.
- W2180473257 cites W1996866382 @default.
- W2180473257 cites W1997046636 @default.
- W2180473257 cites W2002812554 @default.
- W2180473257 cites W2005435407 @default.
- W2180473257 cites W2006652270 @default.
- W2180473257 cites W2008960002 @default.
- W2180473257 cites W2009170266 @default.
- W2180473257 cites W2010895019 @default.
- W2180473257 cites W2021023597 @default.
- W2180473257 cites W2021309429 @default.
- W2180473257 cites W2031672510 @default.
- W2180473257 cites W2034681012 @default.
- W2180473257 cites W2034911894 @default.
- W2180473257 cites W2035765103 @default.
- W2180473257 cites W2042344342 @default.
- W2180473257 cites W2048845468 @default.
- W2180473257 cites W2054317277 @default.
- W2180473257 cites W2054472394 @default.
- W2180473257 cites W2055818701 @default.
- W2180473257 cites W2058054323 @default.
- W2180473257 cites W2064760068 @default.
- W2180473257 cites W2068824007 @default.
- W2180473257 cites W2079724669 @default.
- W2180473257 cites W2085069678 @default.
- W2180473257 cites W2093327629 @default.
- W2180473257 cites W2094629035 @default.
- W2180473257 cites W2100709790 @default.
- W2180473257 cites W2104911178 @default.
- W2180473257 cites W2105779796 @default.
- W2180473257 cites W2107179502 @default.
- W2180473257 cites W2109835678 @default.
- W2180473257 cites W2126450094 @default.
- W2180473257 cites W2126812651 @default.
- W2180473257 cites W2130778425 @default.
- W2180473257 cites W2137062081 @default.
- W2180473257 cites W2144648204 @default.
- W2180473257 cites W2149720080 @default.
- W2180473257 cites W2160249711 @default.
- W2180473257 cites W2166552844 @default.
- W2180473257 cites W2167327887 @default.
- W2180473257 cites W2167760404 @default.
- W2180473257 cites W2167951113 @default.
- W2180473257 doi "https://doi.org/10.1016/j.atherosclerosis.2015.11.009" @default.
- W2180473257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26649902" @default.
- W2180473257 hasPublicationYear "2016" @default.
- W2180473257 type Work @default.
- W2180473257 sameAs 2180473257 @default.
- W2180473257 citedByCount "18" @default.
- W2180473257 countsByYear W21804732572017 @default.
- W2180473257 countsByYear W21804732572018 @default.
- W2180473257 countsByYear W21804732572020 @default.
- W2180473257 countsByYear W21804732572022 @default.
- W2180473257 crossrefType "journal-article" @default.
- W2180473257 hasAuthorship W2180473257A5008421418 @default.
- W2180473257 hasAuthorship W2180473257A5011388364 @default.
- W2180473257 hasAuthorship W2180473257A5014335750 @default.
- W2180473257 hasAuthorship W2180473257A5016569030 @default.
- W2180473257 hasAuthorship W2180473257A5019685555 @default.
- W2180473257 hasAuthorship W2180473257A5025461838 @default.
- W2180473257 hasAuthorship W2180473257A5028351634 @default.
- W2180473257 hasAuthorship W2180473257A5036576116 @default.
- W2180473257 hasAuthorship W2180473257A5038449262 @default.
- W2180473257 hasAuthorship W2180473257A5050519821 @default.
- W2180473257 hasAuthorship W2180473257A5060825242 @default.
- W2180473257 hasAuthorship W2180473257A5086473866 @default.
- W2180473257 hasConcept C11960822 @default.
- W2180473257 hasConcept C126322002 @default.
- W2180473257 hasConcept C134018914 @default.
- W2180473257 hasConcept C1491633281 @default.
- W2180473257 hasConcept C150903083 @default.