Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180486546> ?p ?o ?g. }
- W2180486546 endingPage "1167" @default.
- W2180486546 startingPage "1159" @default.
- W2180486546 abstract "Trans fatty acids (TFA) are considered risk factors for cardiovascular disease (CVD), while the details of distribution and metabolism of the individual isomers are not clear. Here we investigated the accumulation and catabolic rate of TFA positional isomers of octadecenoic acid (18:1) in mice. ICR mice were fed deuterium- and [1-(13)C] stable isotope-labeled trans-9-18:1 (9t-18:1*), trans-10-18:1 (10t-18:1*), or trans-11-18:1 (11t-18:1*) for 2 or 4 weeks, or a TFA mixture (9t-18:1*, 10t-18:1*, and 11t-18:1*) for 3 weeks. Analysis of whole-body tissues by gas chromatography-chemical ionization mass spectrometry revealed the highest 9t-18:1* levels in the heart. Significant differences in the accumulation of the respective trans-18:1 were observed in the heart and erythrocytes, where 9t- > 11t- > 10t-18:1*, but no significant difference was observed in the liver or white adipose tissue (WAT). Mice fed on 11t-18:1 demonstrated accumulation of endogenously synthesized conjugated linoleic acid in the liver, WAT, and heart, but any other metabolites were not found in other groups. Furthermore, we analyzed catabolic rates of single-dose-administered trans-18:1* isomers into [(13)C]-labeled CO2 using isotope-ratio mass spectrometry, and the 10t-18:1*catabolic rate was significantly higher than those of 9t- and 11t-18:1*. We found that the accumulation and catabolism of trans-18:1 positional isomers varied in these mice. Differential accumulation in tissues suggests that individual TFA positional isomers may play different roles in human health." @default.
- W2180486546 created "2016-06-24" @default.
- W2180486546 creator A5001379692 @default.
- W2180486546 creator A5005761329 @default.
- W2180486546 creator A5013618454 @default.
- W2180486546 creator A5016272432 @default.
- W2180486546 creator A5027185726 @default.
- W2180486546 creator A5040490999 @default.
- W2180486546 creator A5045941669 @default.
- W2180486546 creator A5060877282 @default.
- W2180486546 creator A5062924119 @default.
- W2180486546 creator A5070426353 @default.
- W2180486546 creator A5080989540 @default.
- W2180486546 creator A5084014930 @default.
- W2180486546 date "2015-01-01" @default.
- W2180486546 modified "2023-10-01" @default.
- W2180486546 title "<i>Trans</i>-octadecenoic Acid Positional Isomers Have Different Accumulation and Catabolism Properties in Mice" @default.
- W2180486546 cites W1573340454 @default.
- W2180486546 cites W1966743401 @default.
- W2180486546 cites W1974763796 @default.
- W2180486546 cites W1975136745 @default.
- W2180486546 cites W1979202113 @default.
- W2180486546 cites W1990104653 @default.
- W2180486546 cites W1993666625 @default.
- W2180486546 cites W1996823271 @default.
- W2180486546 cites W2002263071 @default.
- W2180486546 cites W2003086599 @default.
- W2180486546 cites W2012318561 @default.
- W2180486546 cites W2023265332 @default.
- W2180486546 cites W2023599729 @default.
- W2180486546 cites W2035311487 @default.
- W2180486546 cites W2042693841 @default.
- W2180486546 cites W2058402996 @default.
- W2180486546 cites W2059479765 @default.
- W2180486546 cites W2060040026 @default.
- W2180486546 cites W2077855373 @default.
- W2180486546 cites W2086000089 @default.
- W2180486546 cites W2095484074 @default.
- W2180486546 cites W2106164651 @default.
- W2180486546 cites W2127772188 @default.
- W2180486546 cites W2133437261 @default.
- W2180486546 cites W2137819942 @default.
- W2180486546 cites W2152500260 @default.
- W2180486546 cites W2159134185 @default.
- W2180486546 cites W2162885005 @default.
- W2180486546 cites W2166073522 @default.
- W2180486546 cites W2166955468 @default.
- W2180486546 cites W2168526937 @default.
- W2180486546 cites W2425372053 @default.
- W2180486546 cites W4255250258 @default.
- W2180486546 cites W2100990283 @default.
- W2180486546 doi "https://doi.org/10.5650/jos.ess15139" @default.
- W2180486546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26521809" @default.
- W2180486546 hasPublicationYear "2015" @default.
- W2180486546 type Work @default.
- W2180486546 sameAs 2180486546 @default.
- W2180486546 citedByCount "4" @default.
- W2180486546 countsByYear W21804865462016 @default.
- W2180486546 countsByYear W21804865462017 @default.
- W2180486546 countsByYear W21804865462021 @default.
- W2180486546 crossrefType "journal-article" @default.
- W2180486546 hasAuthorship W2180486546A5001379692 @default.
- W2180486546 hasAuthorship W2180486546A5005761329 @default.
- W2180486546 hasAuthorship W2180486546A5013618454 @default.
- W2180486546 hasAuthorship W2180486546A5016272432 @default.
- W2180486546 hasAuthorship W2180486546A5027185726 @default.
- W2180486546 hasAuthorship W2180486546A5040490999 @default.
- W2180486546 hasAuthorship W2180486546A5045941669 @default.
- W2180486546 hasAuthorship W2180486546A5060877282 @default.
- W2180486546 hasAuthorship W2180486546A5062924119 @default.
- W2180486546 hasAuthorship W2180486546A5070426353 @default.
- W2180486546 hasAuthorship W2180486546A5080989540 @default.
- W2180486546 hasAuthorship W2180486546A5084014930 @default.
- W2180486546 hasBestOaLocation W21804865461 @default.
- W2180486546 hasConcept C151955695 @default.
- W2180486546 hasConcept C171089720 @default.
- W2180486546 hasConcept C176788430 @default.
- W2180486546 hasConcept C185592680 @default.
- W2180486546 hasConcept C202235601 @default.
- W2180486546 hasConcept C2779780233 @default.
- W2180486546 hasConcept C2780809830 @default.
- W2180486546 hasConcept C43617362 @default.
- W2180486546 hasConcept C543025807 @default.
- W2180486546 hasConcept C55493867 @default.
- W2180486546 hasConcept C62231903 @default.
- W2180486546 hasConcept C71240020 @default.
- W2180486546 hasConcept C96942376 @default.
- W2180486546 hasConceptScore W2180486546C151955695 @default.
- W2180486546 hasConceptScore W2180486546C171089720 @default.
- W2180486546 hasConceptScore W2180486546C176788430 @default.
- W2180486546 hasConceptScore W2180486546C185592680 @default.
- W2180486546 hasConceptScore W2180486546C202235601 @default.
- W2180486546 hasConceptScore W2180486546C2779780233 @default.
- W2180486546 hasConceptScore W2180486546C2780809830 @default.
- W2180486546 hasConceptScore W2180486546C43617362 @default.
- W2180486546 hasConceptScore W2180486546C543025807 @default.
- W2180486546 hasConceptScore W2180486546C55493867 @default.
- W2180486546 hasConceptScore W2180486546C62231903 @default.