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- W2180493842 endingPage "174" @default.
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- W2180493842 abstract "Cardiac fibrosis is one of the major components of the healing mechanism following any injury of the heart and as such may contribute to both systolic and diastolic dysfunction in a range of pathophysiologic conditions. Canonically, it can occur as part of the remodeling process that occurs following myocardial infarction or that follows as a response to pressure overload. Integrins are cell surface receptors which act in both cellular adhesion and signaling. Most importantly, in the context of the continuously contracting myocardium, they are recognized as mechanotransducers. They have been implicated in the development of fibrosis in several organs, including the heart. This review will focus on the involvement of integrins and integrin-related proteins, in cardiac fibrosis, outlining the roles of these proteins in the fibrotic responses in specific cardiac pathologies, discuss some of the common end effectors (angiotensin II, transforming growth factor beta 1 and mechanical stress) through which integrins function and finally discuss how manipulation of this set of proteins may lead to new treatments which could prove useful to alter the deleterious effects of cardiac fibrosis." @default.
- W2180493842 created "2016-06-24" @default.
- W2180493842 creator A5001128153 @default.
- W2180493842 creator A5039775565 @default.
- W2180493842 creator A5049101165 @default.
- W2180493842 creator A5056248574 @default.
- W2180493842 date "2016-04-01" @default.
- W2180493842 modified "2023-10-13" @default.
- W2180493842 title "Integrins and integrin-related proteins in cardiac fibrosis" @default.
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