FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180507727> ?p ?o ?g. }

• W2180507727 endingPage "64" @default.
• W2180507727 startingPage "48" @default.
• W2180507727 abstract "Tangeretin, a major phytochemicals in tangerine peels - an important Chinese herb, has been found to have anti-carcinogenic properties. To improve bioavailability and increase potency of tangeretin, its derivative, 5-acetyloxy-6,7,8,4′-tetramethoxyflavone (5-AcTMF), has been synthesized and shown potent inhibition of proliferation activity against human breast and leukemia cancer cell lines. In this study, we have further investigated the anticancer effects of 5-AcTMF on CL1-5 non-small cell lung cancer cells (NSCLC) both in vitro and in vivo and demonstrated that 5-AcTMF effectively inhibited cancer cell proliferation, induced G2/M-phase arrest associated with cdc2 and CDC25c and increased in the apoptotic cells associated with caspase activation, down regulation of Bcl-2, XIAP and Survivn, inducing release of cytochrome c into the cytosol and disruption of mitochondrial membrane potential. We also found that 5-AcTMF treatment of CL1-5 activated autophagy, indicated by triggered autophagosome formation and increased LC3-II levels and formation of LC3 puncta. Moreover, we also found that 5-AcTMF lowered phophoatidylinositol 3-kinase/AKT/mTOR signaling pathway. Over-expression of AKT by AKT cDNA transfection decreased 5-AcTMF mediated apoptosis and autophagy, supporting the induction of apoptosis and autophagy by inhibition of AKT pathway. In an animal study, 5-AcTMF effectively delayed tumor growth in a nude mouse model of CL1-5 xenografts without observed adverse effect. Immunohistochemistry Analysis indicated that 5-AcTMF induced CL1-5 cell apoptosis and autophagy in vivo. Taken together, these data demonstrate that 5-AcTMF is a novel small molecule agent that can inhibit NSCLC cell proliferation, and induce G(2)/M phase arrest and via the mitochondrial apoptotic pathway and autophagy." @default.
• W2180507727 created "2016-06-24" @default.
• W2180507727 creator A5010500131 @default.
• W2180507727 creator A5010926516 @default.
• W2180507727 creator A5016100867 @default.
• W2180507727 creator A5019775891 @default.
• W2180507727 creator A5020517811 @default.
• W2180507727 creator A5025476574 @default.
• W2180507727 creator A5036062527 @default.
• W2180507727 creator A5042409403 @default.
• W2180507727 creator A5044484654 @default.
• W2180507727 date "2015-11-16" @default.
• W2180507727 modified "2023-10-15" @default.
• W2180507727 title "Tangeretin derivative, 5-acetyloxy-6,7,8,4′-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo" @default.
• W2180507727 cites W1640635403 @default.
• W2180507727 cites W1740332796 @default.
• W2180507727 cites W1969690844 @default.
• W2180507727 cites W1972090863 @default.
• W2180507727 cites W1977062227 @default.
• W2180507727 cites W1977943009 @default.
• W2180507727 cites W1981805063 @default.
• W2180507727 cites W1983346143 @default.
• W2180507727 cites W1986301158 @default.
• W2180507727 cites W1991774590 @default.
• W2180507727 cites W2001675597 @default.
• W2180507727 cites W2003851398 @default.
• W2180507727 cites W2015860478 @default.
• W2180507727 cites W2016347688 @default.
• W2180507727 cites W2017089492 @default.
• W2180507727 cites W2021074776 @default.
• W2180507727 cites W2027410239 @default.
• W2180507727 cites W2035099443 @default.
• W2180507727 cites W2035658420 @default.
• W2180507727 cites W2038444072 @default.
• W2180507727 cites W2041868010 @default.
• W2180507727 cites W2049275490 @default.
• W2180507727 cites W2050648642 @default.
• W2180507727 cites W2061178082 @default.
• W2180507727 cites W2061801920 @default.
• W2180507727 cites W2064306504 @default.
• W2180507727 cites W2079387502 @default.
• W2180507727 cites W2083911670 @default.
• W2180507727 cites W2084733602 @default.
• W2180507727 cites W2085822109 @default.
• W2180507727 cites W2087861588 @default.
• W2180507727 cites W2089356742 @default.
• W2180507727 cites W2090992646 @default.
• W2180507727 cites W2092162166 @default.
• W2180507727 cites W2093912551 @default.
• W2180507727 cites W2105263081 @default.
• W2180507727 cites W2108918284 @default.
• W2180507727 cites W2120210411 @default.
• W2180507727 cites W2122404306 @default.
• W2180507727 cites W2123397817 @default.
• W2180507727 cites W2123692379 @default.
• W2180507727 cites W2125349840 @default.
• W2180507727 cites W2126376871 @default.
• W2180507727 cites W2127153258 @default.
• W2180507727 cites W2128267563 @default.
• W2180507727 cites W2151786805 @default.
• W2180507727 cites W2153890808 @default.
• W2180507727 cites W2169961966 @default.
• W2180507727 cites W2219978888 @default.
• W2180507727 cites W2331384567 @default.
• W2180507727 cites W3152192648 @default.
• W2180507727 cites W329007366 @default.
• W2180507727 doi "https://doi.org/10.1080/15384047.2015.1108491" @default.
• W2180507727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4847812" @default.
• W2180507727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26569090" @default.
• W2180507727 hasPublicationYear "2015" @default.
• W2180507727 type Work @default.
• W2180507727 sameAs 2180507727 @default.
• W2180507727 citedByCount "32" @default.
• W2180507727 countsByYear W21805077272016 @default.
• W2180507727 countsByYear W21805077272017 @default.
• W2180507727 countsByYear W21805077272018 @default.
• W2180507727 countsByYear W21805077272019 @default.
• W2180507727 countsByYear W21805077272020 @default.
• W2180507727 countsByYear W21805077272021 @default.
• W2180507727 countsByYear W21805077272022 @default.
• W2180507727 countsByYear W21805077272023 @default.
• W2180507727 crossrefType "journal-article" @default.
• W2180507727 hasAuthorship W2180507727A5010500131 @default.
• W2180507727 hasAuthorship W2180507727A5010926516 @default.
• W2180507727 hasAuthorship W2180507727A5016100867 @default.
• W2180507727 hasAuthorship W2180507727A5019775891 @default.
• W2180507727 hasAuthorship W2180507727A5020517811 @default.
• W2180507727 hasAuthorship W2180507727A5025476574 @default.
• W2180507727 hasAuthorship W2180507727A5036062527 @default.
• W2180507727 hasAuthorship W2180507727A5042409403 @default.
• W2180507727 hasAuthorship W2180507727A5044484654 @default.
• W2180507727 hasBestOaLocation W21805077271 @default.
• W2180507727 hasConcept C105696609 @default.
• W2180507727 hasConcept C150903083 @default.
• W2180507727 hasConcept C185592680 @default.
• W2180507727 hasConcept C190283241 @default.
• W2180507727 hasConcept C203522944 @default.
• W2180507727 hasConcept C207001950 @default.

• next