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- W2180661013 abstract "The treatment of cancer has traditionally been based on the identification of a single molecule and/or enzymatic function (target) responsible for a particular phenotype, and therefore on the ability to stimulate, attenuate or inhibit its activity through the use of selective compounds. However, cancer is no longer considered a disease caused by a single factor, but is now recognized as a multi-factorial disorder. Genetic, epigenetic and metabolic factors all contribute to neoplasia, causing significant changes in molecular networks that govern cell growth, development, death and specialization. Consequently, many antitumor therapies are no longer directed against a single target but the biological system as a whole, in which functions determining the onset and maintenance of a physio-pathological state are modulated. The field of epi-drug discovery is currently in a transitional phase where the search for putative anticancer drugs is shifting from single-target-oriented molecules to network-active compounds and to epi-drugs used in combination with other epi-agents and with traditional chemotherapeutics. This review illustrates the pros and cons of each therapeutic option, providing examples in support of single-target and multi (network)-target epi-drug approaches." @default.
- W2180661013 created "2016-06-24" @default.
- W2180661013 creator A5009160904 @default.
- W2180661013 creator A5039682482 @default.
- W2180661013 creator A5072208146 @default.
- W2180661013 creator A5078908851 @default.
- W2180661013 date "2015-12-01" @default.
- W2180661013 modified "2023-10-14" @default.
- W2180661013 title "Epigenetic-based therapy: From single- to multi-target approaches" @default.
- W2180661013 cites W1517653507 @default.
- W2180661013 cites W1554188613 @default.
- W2180661013 cites W1595597462 @default.
- W2180661013 cites W1873710893 @default.
- W2180661013 cites W1945032888 @default.
- W2180661013 cites W1963736125 @default.
- W2180661013 cites W1964827067 @default.
- W2180661013 cites W1965692362 @default.
- W2180661013 cites W1971004265 @default.
- W2180661013 cites W1971382122 @default.
- W2180661013 cites W1973059973 @default.
- W2180661013 cites W1973822320 @default.
- W2180661013 cites W1974456689 @default.
- W2180661013 cites W1975267683 @default.
- W2180661013 cites W1976033223 @default.
- W2180661013 cites W1978047155 @default.
- W2180661013 cites W1979157667 @default.
- W2180661013 cites W1980009033 @default.
- W2180661013 cites W1982085112 @default.
- W2180661013 cites W1986642686 @default.
- W2180661013 cites W1986929921 @default.
- W2180661013 cites W1987835971 @default.
- W2180661013 cites W1990174038 @default.
- W2180661013 cites W1990260147 @default.
- W2180661013 cites W1990996412 @default.
- W2180661013 cites W1995275377 @default.
- W2180661013 cites W1995557117 @default.
- W2180661013 cites W1998957807 @default.
- W2180661013 cites W2004380688 @default.
- W2180661013 cites W2005448885 @default.
- W2180661013 cites W2007510497 @default.
- W2180661013 cites W2017492512 @default.
- W2180661013 cites W2021710587 @default.
- W2180661013 cites W2022949290 @default.
- W2180661013 cites W2024373518 @default.
- W2180661013 cites W2024469844 @default.
- W2180661013 cites W2027741880 @default.
- W2180661013 cites W2029457245 @default.
- W2180661013 cites W2035286495 @default.
- W2180661013 cites W2035411102 @default.
- W2180661013 cites W2036700704 @default.
- W2180661013 cites W2038320708 @default.
- W2180661013 cites W2039107968 @default.
- W2180661013 cites W2040996880 @default.
- W2180661013 cites W2041535798 @default.
- W2180661013 cites W2042919041 @default.
- W2180661013 cites W2046345187 @default.
- W2180661013 cites W2046874217 @default.
- W2180661013 cites W2047790609 @default.
- W2180661013 cites W2047867594 @default.
- W2180661013 cites W2047966004 @default.
- W2180661013 cites W2048122601 @default.
- W2180661013 cites W2051113417 @default.
- W2180661013 cites W2051207198 @default.
- W2180661013 cites W2052787205 @default.
- W2180661013 cites W2054702892 @default.
- W2180661013 cites W2055072555 @default.
- W2180661013 cites W2056181477 @default.
- W2180661013 cites W2060707415 @default.
- W2180661013 cites W2062828530 @default.
- W2180661013 cites W2063073998 @default.
- W2180661013 cites W2063092678 @default.
- W2180661013 cites W2063887542 @default.
- W2180661013 cites W2064221635 @default.
- W2180661013 cites W2066715607 @default.
- W2180661013 cites W2070221969 @default.
- W2180661013 cites W2071576183 @default.
- W2180661013 cites W2078521443 @default.
- W2180661013 cites W2080504792 @default.
- W2180661013 cites W2081675364 @default.
- W2180661013 cites W2082592723 @default.
- W2180661013 cites W2083627942 @default.
- W2180661013 cites W2083898865 @default.
- W2180661013 cites W2084295010 @default.
- W2180661013 cites W2085913537 @default.
- W2180661013 cites W2091208410 @default.
- W2180661013 cites W2094851085 @default.
- W2180661013 cites W2096864392 @default.
- W2180661013 cites W2098087062 @default.
- W2180661013 cites W2099754222 @default.
- W2180661013 cites W2100630390 @default.
- W2180661013 cites W2101353517 @default.
- W2180661013 cites W2104954848 @default.
- W2180661013 cites W2105391162 @default.
- W2180661013 cites W2105906697 @default.
- W2180661013 cites W2106556931 @default.
- W2180661013 cites W2108069034 @default.
- W2180661013 cites W2115707319 @default.
- W2180661013 cites W2116851173 @default.