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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180740327> ?p ?o ?g. }

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• W2180740327 abstract "Optimization of benzimidazole 5-carboxamide derivatives previously identified as specific inhibitors of the NS5B polymerase of the hepatitis C virus (HCV) has led to the discovery of potent analogues that inhibit the enzyme at low-nanomolar concentrations. Greater than 800-fold improvement in potency from the original lead structure was achieved through the combined effects of conformational rigidification, molecular size extension and the identification of previously unexploited interactions. Furthermore, these inhibitors retain specificity for HCV polymerase relative to other viral and mammalian RNA polymerases." @default.
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• W2180740327 date "2004-02-01" @default.
• W2180740327 modified "2023-10-16" @default.
• W2180740327 title "Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency" @default.
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• W2180740327 doi "https://doi.org/10.1016/j.bmcl.2003.12.032" @default.
• W2180740327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15013003" @default.
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