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- W218074920 abstract "We have developed radioimmunoassays that detect idiotypic (variable region) differences among the ..cap alpha..(1 ..-->.. 3) dextran-binding myeloma proteins U102, J558, and M104 as well as an assay that detects variable region determinants common to all three proteins. Using these assays, we have examined 7S and 19S anti-..cap alpha..(1 ..-->.. 3) dextran antibodies induced in five murine strains of the a/sup 1/I/sub g/C/sub H/ linkage group and the recombinant strain BAB/14. All idiotypes were expressed in both 19S and 7S antibodies from all strains, but with considerable strain-specific variability in penetrance. In two strains, one additional type of antibody, which lacked all four idiotypic determinants, generally constituted the bulk of total anti-..cap alpha..(1 ..-->.. 3) dextran antibodies." @default.
- W218074920 created "2016-06-24" @default.
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- W218074920 date "1977-10-01" @default.
- W218074920 modified "2023-09-27" @default.
- W218074920 title "Analysis of the diversity of murine antibodies to dextran B1355. II. Demonstration of multiple idiotypes with variable expression in several strains. [Radioimmunoassay, /sup 125/I tracer technique]" @default.
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