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- W2180800667 abstract "We would like to thank Marrs et al. for their critical appraisal of our paper in The Lancet.1 We appreciate the authors’ comments regarding the quality of the STOP II trial conduct and reporting, and share their view that this study represents an important addition to the existing published studies on peanut oral immunotherapy (OIT). In response to their appraisal, we would like to take this opportunity to present our comments. The stated aim of our study was to assess desensitization to peanut for up to 6 months, not long‐term tolerance. Previous studies have shown that tolerance attainment at this early time point is rare, but tolerance attainment is not necessarily the aim of treatment. Our study showed that desensitization resulted in an improvement in quality of life, due to improvement in emotional, social and anxiety scores. Long‐term protection from accidental ingestion, and relaxation of avoidance practice may be achieved by continued desensitization, which seems a reasonable aim for treatment given the shortcomings of the current standard of care. This approach is in agreement with the stated purpose of the trial,1 and therefore does not compromise internal validity." @default.
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- W2180800667 date "2015-11-01" @default.
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- W2180800667 title "Author response to Marrs<i>et al</i>., Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial: a critical appraisal" @default.
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- W2180800667 doi "https://doi.org/10.1111/bjd.14160" @default.
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