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• W2180872719 abstract "Capreomycin sulfate (CS), a mixture of 4 closely related compounds (powder mainly comprised of 2 forms), commonly injected intramuscularly is intended to be administer by inhalation for the treatment of pulmonary tuberculosis. In order to increase the drug residence time in the lung, capreomycin hydrophobicity was enhanced by substituting sulfate with oleate, thus obtaining capreomycin oleate (CO). The generation of a more hydrophobic ion-pair allows the reduction of the drug solubilisation in the bronchoalveolar fluids as well as its systemic absorption. The aim of the present study was to quantify CO in an in-house prepared drug formulation for inhalation. In this regard, a Hydrophilic Liquid Interaction Chromatography (HILIC) method was optimized with acetonitrile (ACN)/water containing eluents and a diol-type stationary phase. The optimal eluent composition [ACN/water-80/20 (v/v), 20mM ammonium formate, 3.0 wspH] produced a good separation (α equal to 1.15) between the two main peaks. The developed HILIC method succeeded in the quantitative assay of CO in the drug formulation and was fully validated. Very good precision and accuracy in the short- and long-period along with appreciably low LOD and LOQ values (respectively 1.75 and 5.25μg/mL) turned out." @default.
• W2180872719 created "2016-06-24" @default.
• W2180872719 creator A5034280862 @default.
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• W2180872719 date "2016-02-01" @default.
• W2180872719 modified "2023-09-23" @default.
• W2180872719 title "Quantitative assay of capreomycin oleate levels in a drug formulation for inhalation with a fully validated HPLC method" @default.
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• W2180872719 doi "https://doi.org/10.1016/j.jpba.2015.11.040" @default.
• W2180872719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26680112" @default.
• W2180872719 hasPublicationYear "2016" @default.
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