FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180877365> ?p ?o ?g. }

• W2180877365 endingPage "2120" @default.
• W2180877365 startingPage "2117" @default.
• W2180877365 abstract "The 3'-iodo positional isomer of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT) and other 3'-substituted analogs were synthesized and evaluated for binding to monoamine transporters in rat forebrain and membranes of cell lines selectively expressing human transporter genes. All 3'-substituted compounds displayed affinity for both serotonin (SERT) and dopamine (DAT), but much less for norepinephrine transporters (NET), with selectivity for rat (r) or human (h) SERT over NET, but only 3'-iodo-substituted phenyltropanes showed selectivity for SERT versus DAT. The 3'-iodo, N-methyl analog of beta-CIT (7) displayed 29-fold selectivity and high affinity for hSERT (K(i) =9.6 nM) over hDAT (K(i) =279 nM), and its nor-congener (8) showed even higher hSERT potency (K(i) =1.2 nM) and selectivity over DAT (415-fold)." @default.
• W2180877365 created "2016-06-24" @default.
• W2180877365 creator A5000680884 @default.
• W2180877365 creator A5025091145 @default.
• W2180877365 creator A5030055089 @default.
• W2180877365 creator A5061306010 @default.
• W2180877365 creator A5066655151 @default.
• W2180877365 creator A5079125204 @default.
• W2180877365 date "2004-05-01" @default.
• W2180877365 modified "2023-09-27" @default.
• W2180877365 title "Synthesis and monoamine transporter affinity of 3′-analogs of 2-β-carbomethoxy-3-β-(4′-iodophenyl)tropane (β-CIT)" @default.
• W2180877365 cites W1606062035 @default.
• W2180877365 cites W1618289512 @default.
• W2180877365 cites W1976749972 @default.
• W2180877365 cites W1979607966 @default.
• W2180877365 cites W1980606076 @default.
• W2180877365 cites W1984487619 @default.
• W2180877365 cites W1985888600 @default.
• W2180877365 cites W1990463755 @default.
• W2180877365 cites W1992618914 @default.
• W2180877365 cites W1995336461 @default.
• W2180877365 cites W2014793858 @default.
• W2180877365 cites W2020024663 @default.
• W2180877365 cites W2063242294 @default.
• W2180877365 cites W2070796637 @default.
• W2180877365 cites W2084515792 @default.
• W2180877365 cites W2090481799 @default.
• W2180877365 cites W2090715212 @default.
• W2180877365 cites W2095217951 @default.
• W2180877365 cites W2108750731 @default.
• W2180877365 cites W2108772304 @default.
• W2180877365 cites W2168036028 @default.
• W2180877365 cites W2405556557 @default.
• W2180877365 cites W2464687139 @default.
• W2180877365 cites W2951040009 @default.
• W2180877365 cites W2952698597 @default.
• W2180877365 cites W3029271321 @default.
• W2180877365 doi "https://doi.org/10.1016/j.bmcl.2004.02.043" @default.
• W2180877365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15080991" @default.
• W2180877365 hasPublicationYear "2004" @default.
• W2180877365 type Work @default.
• W2180877365 sameAs 2180877365 @default.
• W2180877365 citedByCount "20" @default.
• W2180877365 countsByYear W21808773652013 @default.
• W2180877365 countsByYear W21808773652014 @default.
• W2180877365 countsByYear W21808773652015 @default.
• W2180877365 countsByYear W21808773652019 @default.
• W2180877365 countsByYear W21808773652020 @default.
• W2180877365 crossrefType "journal-article" @default.
• W2180877365 hasAuthorship W2180877365A5000680884 @default.
• W2180877365 hasAuthorship W2180877365A5025091145 @default.
• W2180877365 hasAuthorship W2180877365A5030055089 @default.
• W2180877365 hasAuthorship W2180877365A5061306010 @default.
• W2180877365 hasAuthorship W2180877365A5066655151 @default.
• W2180877365 hasAuthorship W2180877365A5079125204 @default.
• W2180877365 hasConcept C104317684 @default.
• W2180877365 hasConcept C118792377 @default.
• W2180877365 hasConcept C134018914 @default.
• W2180877365 hasConcept C149011108 @default.
• W2180877365 hasConcept C161790260 @default.
• W2180877365 hasConcept C170493617 @default.
• W2180877365 hasConcept C176233148 @default.
• W2180877365 hasConcept C185592680 @default.
• W2180877365 hasConcept C187714386 @default.
• W2180877365 hasConcept C202751555 @default.
• W2180877365 hasConcept C2775864247 @default.
• W2180877365 hasConcept C2776755682 @default.
• W2180877365 hasConcept C2776995303 @default.
• W2180877365 hasConcept C2778897192 @default.
• W2180877365 hasConcept C513476851 @default.
• W2180877365 hasConcept C55493867 @default.
• W2180877365 hasConcept C57992300 @default.
• W2180877365 hasConcept C71240020 @default.
• W2180877365 hasConcept C86803240 @default.
• W2180877365 hasConceptScore W2180877365C104317684 @default.
• W2180877365 hasConceptScore W2180877365C118792377 @default.
• W2180877365 hasConceptScore W2180877365C134018914 @default.
• W2180877365 hasConceptScore W2180877365C149011108 @default.
• W2180877365 hasConceptScore W2180877365C161790260 @default.
• W2180877365 hasConceptScore W2180877365C170493617 @default.
• W2180877365 hasConceptScore W2180877365C176233148 @default.
• W2180877365 hasConceptScore W2180877365C185592680 @default.
• W2180877365 hasConceptScore W2180877365C187714386 @default.
• W2180877365 hasConceptScore W2180877365C202751555 @default.
• W2180877365 hasConceptScore W2180877365C2775864247 @default.
• W2180877365 hasConceptScore W2180877365C2776755682 @default.
• W2180877365 hasConceptScore W2180877365C2776995303 @default.
• W2180877365 hasConceptScore W2180877365C2778897192 @default.
• W2180877365 hasConceptScore W2180877365C513476851 @default.
• W2180877365 hasConceptScore W2180877365C55493867 @default.
• W2180877365 hasConceptScore W2180877365C57992300 @default.
• W2180877365 hasConceptScore W2180877365C71240020 @default.
• W2180877365 hasConceptScore W2180877365C86803240 @default.
• W2180877365 hasIssue "9" @default.
• W2180877365 hasLocation W21808773651 @default.
• W2180877365 hasLocation W21808773652 @default.
• W2180877365 hasOpenAccess W2180877365 @default.
• W2180877365 hasPrimaryLocation W21808773651 @default.

• next