Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180948174> ?p ?o ?g. }
- W2180948174 endingPage "84" @default.
- W2180948174 startingPage "75" @default.
- W2180948174 abstract "Polarization of tumor infiltrating macrophages is associated with the prognosis of solid malignancies and correlates with the occurrence of lymph node metastases in oral squamous cell carcinomas (oscc). Early stage (T1/T2, N0) oscc are characterized by a good prognosis and can be cured by surgery. The postoperative regime usually contains no adjuvant radio-/chemotherapy. The current pilot study was conducted to elucidate whether macrophage polarization in tumor resection specimens and diagnostic biopsies of early stage oscc is associated with tumor outcome.Patients with T1/T2, N0, and R0>5mm oscc without adjuvant therapy and 3-year follow-up after tumor resection were retrospectively selected. Tissue microarrays (TMA) containing diagnostic biopsies (n=17) and tumor resection specimens (n=17) were processed for immunohistochemistry in this pilot study to detect CD68-, CD11c-, CD163- and MRC1-positive macrophages. Samples were digitized, and the expression of macrophage markers was quantitatively analyzed.High infiltration of M2 polarized macrophages correlated with poor tumor outcome in early stage (T1/T2, N0) oscc. This correlation was observed in tumor resection specimens, but was also observed in diagnostic biopsies. M2 macrophage polarization in biopsies - but not in tumor resection samples - correlated with high scores in tumor grading.Macrophage polarization in early stage oscc is a potential prognostic marker for tumor outcome. The correlation of M2 polarized macrophages with tumor outcome can already be detected in the initial biopsies. Furthermore, M2 polarization of macrophages in biopsies is associated with an increased dedifferentiation." @default.
- W2180948174 created "2016-06-24" @default.
- W2180948174 creator A5010598883 @default.
- W2180948174 creator A5014092853 @default.
- W2180948174 creator A5018575155 @default.
- W2180948174 creator A5039736409 @default.
- W2180948174 creator A5051985691 @default.
- W2180948174 creator A5058960567 @default.
- W2180948174 creator A5080720097 @default.
- W2180948174 creator A5083147178 @default.
- W2180948174 creator A5089138372 @default.
- W2180948174 date "2016-01-01" @default.
- W2180948174 modified "2023-09-26" @default.
- W2180948174 title "Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas" @default.
- W2180948174 cites W1485965823 @default.
- W2180948174 cites W1512626650 @default.
- W2180948174 cites W1517360973 @default.
- W2180948174 cites W1571559303 @default.
- W2180948174 cites W1797422316 @default.
- W2180948174 cites W1824475845 @default.
- W2180948174 cites W1899192341 @default.
- W2180948174 cites W1965569235 @default.
- W2180948174 cites W1980485314 @default.
- W2180948174 cites W1981505729 @default.
- W2180948174 cites W1986981837 @default.
- W2180948174 cites W1990266269 @default.
- W2180948174 cites W2003620074 @default.
- W2180948174 cites W2003802285 @default.
- W2180948174 cites W2011495787 @default.
- W2180948174 cites W2012616131 @default.
- W2180948174 cites W2020087055 @default.
- W2180948174 cites W2024094193 @default.
- W2180948174 cites W2026928416 @default.
- W2180948174 cites W2032171199 @default.
- W2180948174 cites W2039836740 @default.
- W2180948174 cites W2040560677 @default.
- W2180948174 cites W2045012199 @default.
- W2180948174 cites W2047600616 @default.
- W2180948174 cites W2050636009 @default.
- W2180948174 cites W2054472394 @default.
- W2180948174 cites W2055421595 @default.
- W2180948174 cites W2066469619 @default.
- W2180948174 cites W2070855360 @default.
- W2180948174 cites W2074198606 @default.
- W2180948174 cites W2074942026 @default.
- W2180948174 cites W2077731584 @default.
- W2180948174 cites W2078490888 @default.
- W2180948174 cites W2081432712 @default.
- W2180948174 cites W2083972280 @default.
- W2180948174 cites W2086756221 @default.
- W2180948174 cites W2106027870 @default.
- W2180948174 cites W2108276819 @default.
- W2180948174 cites W2113082145 @default.
- W2180948174 cites W2122359995 @default.
- W2180948174 cites W2123487123 @default.
- W2180948174 cites W2132564070 @default.
- W2180948174 cites W2143293161 @default.
- W2180948174 cites W2153767355 @default.
- W2180948174 cites W2157725506 @default.
- W2180948174 cites W2170553216 @default.
- W2180948174 cites W2172089049 @default.
- W2180948174 cites W52273448 @default.
- W2180948174 doi "https://doi.org/10.1016/j.oraloncology.2015.11.001" @default.
- W2180948174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26728105" @default.
- W2180948174 hasPublicationYear "2016" @default.
- W2180948174 type Work @default.
- W2180948174 sameAs 2180948174 @default.
- W2180948174 citedByCount "60" @default.
- W2180948174 countsByYear W21809481742016 @default.
- W2180948174 countsByYear W21809481742017 @default.
- W2180948174 countsByYear W21809481742018 @default.
- W2180948174 countsByYear W21809481742019 @default.
- W2180948174 countsByYear W21809481742020 @default.
- W2180948174 countsByYear W21809481742021 @default.
- W2180948174 countsByYear W21809481742022 @default.
- W2180948174 countsByYear W21809481742023 @default.
- W2180948174 crossrefType "journal-article" @default.
- W2180948174 hasAuthorship W2180948174A5010598883 @default.
- W2180948174 hasAuthorship W2180948174A5014092853 @default.
- W2180948174 hasAuthorship W2180948174A5018575155 @default.
- W2180948174 hasAuthorship W2180948174A5039736409 @default.
- W2180948174 hasAuthorship W2180948174A5051985691 @default.
- W2180948174 hasAuthorship W2180948174A5058960567 @default.
- W2180948174 hasAuthorship W2180948174A5080720097 @default.
- W2180948174 hasAuthorship W2180948174A5083147178 @default.
- W2180948174 hasAuthorship W2180948174A5089138372 @default.
- W2180948174 hasConcept C142724271 @default.
- W2180948174 hasConcept C143998085 @default.
- W2180948174 hasConcept C146357865 @default.
- W2180948174 hasConcept C151730666 @default.
- W2180948174 hasConcept C18903297 @default.
- W2180948174 hasConcept C193270364 @default.
- W2180948174 hasConcept C202751555 @default.
- W2180948174 hasConcept C204232928 @default.
- W2180948174 hasConcept C2775858924 @default.
- W2180948174 hasConcept C2775934546 @default.
- W2180948174 hasConcept C2776460901 @default.
- W2180948174 hasConcept C2776682551 @default.