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• W2180972298 abstract "Background: Malignant mesotheliomas reportedly secrete interleukin-6 (IL-6) which augments production of vascular endothelial growth factor (VEGF) from mesothelioma cells. We previously reported the development of a new receptor inhibitor of IL-6 (NRI) by genetically engineering tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody. Since NRI is encoded on a single gene, it is easily applicable to a gene delivery system using virus vehicles. In this study, we report VEGF targeting through NRI expression based on adenovirus-mediated gene delivery in mesothelioma cells. Materials and Methods: We constructed an NRI expression vector in the context of a tropism-modified adenovirus vector that had enhanced infectivity in mesothelioma cells. Results: This virus effectively induced NRI secretion from mesothelioma cells. This virus infection also reduced the VEGF production in mesothelioma cells. Conclusion: These results indicate that NRI shows potential as an agent in the treatment of mesotheliomas." @default.
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• W2180972298 date "2010-06-01" @default.
• W2180972298 modified "2023-09-23" @default.
• W2180972298 title "VEGF targeting in mesotheliomas using an interleukin-6 signal inhibitor based on adenovirus gene delivery." @default.
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