FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2180980934> ?p ?o ?g. }

• W2180980934 endingPage "92" @default.
• W2180980934 startingPage "91" @default.
• W2180980934 abstract "Anterocollis or antecollis, also called dropped head, is characterized by disproportionate flexion of the head over the trunk and can result from either muscle weakness (i.e., myasthenia gravis and motor neuron disease) or muscle hyperactivity in cases of dystonia.1 Anterocollis has been described in patients with Parkinson's disease (PD) or multiple system atrophy; however, it is still debated whether, in these cases, it is dystonic in nature or myopathic or both2, 3 Anterocollis has also been described with use of antiparkinsonian medications, such as amantadine and certain dopamine agonists (DAs; cabergoline, pramipexole, or rotigotine).2-7 We report here videotape evidence of anterocollis development secondary to ropinirole use, with full recovery after drug discontinuation. A 76-year-old man referred mood changes and apathy developing during the last 10 years. Soon after, he began to experience difficulty walking, needing to take shorter steps, and also referred clumsiness when using his hands. At the initial consultation, the patient referred symptoms consistent with rapid eye movement sleep behavior disorder, olfactory impairment, and chronic constipation as well as progressive immobilization. On the other hand, he denied urinary incontinence or syncope. After the diagnosis of PD was confirmed, he started levodopa four times a day. Symptoms progressed over a 10-year period with evident cognitive impairment in the last 2 years. The patient was treated with 675 mg of an l-dopa/carbidopa combination on a three times daily basis, along with 30 mg of duloxetine and 5 mg of donepezil daily, and 4 mg of extended-release ropinirole. On physical examination, 2 hours after his usual l-dopa dose, his International Parkinson and Movement Disorder Society/UPDRS Part III score was of 31 points. At the same time, his H & Y was 3 and Mini–Mental State Examination score was 27/30. The patient presented no “red flags” for atypical parkinsonism. Last year, the patient developed a peptic ulcer, which required admission to the intensive care unit for 16 days. He developed transient delirium during his hospitalization and was treated with clozapine. Ropinirole, however, had to be withdrawn in order to resolve psychotic symptoms. One month later, clozapine was discontinued and ropinirole was progressively reintroduced with an initial dose of 8 mg and then increased to 12 mg. Two weeks after starting the 12-mg dose, he developed progressive anterocollis and slight camptocormia (see Video 1, left panel), to a degree in which his chin fell down and came into contact with his chest. Both active and passive mobilization of the neck was difficult. A simultaneous surface electromyography (EMG) was performed on the neck muscles, at rest (for 1 minute), during head rotation, tilt to either side, and during head flexion and extension. Both sternocleidomastoid and trapezius muscles showed signs of cocontraction. No signs of fasciculation or denervation were found in either muscle. Routine lab workup showed normal creatine kinase, aldolase, thyroid hormones, and acetylcholine receptor antibody values. Owing to the rapid symptom onset and the link to ropinirole increase, the drug was withdrawn. Four months after drug discontinuation, anterocollis completely resolved, although the cardinal symptoms of PD significantly deteriorated (see Video 1, right panel). Although postural disturbances are common in PD, mainly associated with the disease itself, they can also be caused or worsened by medication.8, 9 Despite that DA-induced anterocollis has been previously reported, this is, to our knowledge, the first case associated with ropinirole use, confirming its dystonic nature. Still, 1 case of reversible Pisa syndrome associated with ropinirole in a PD patient has been previously described.10 Pathophysiology of anterocollis in PD is controversial, given that it is believed to be generated either by disproportionate neck muscle tone of both extensors and flexors, or through dystonia or myopathy of the extensor muscles.2, 3, 7 In this case, surface EMG showed cocontraction of extensor and flexor neck muscles without evidence of myopathy, thus favoring a dystonic etiology. Risk factors related to anterocollis and similar dystonic features in PD besides DAs are age, disease duration, dementia, and female gender.3, 8, 9 Clinicians treating PD patients should consider DAs as a potential source of anterocollis syndrome. (1) Research project: A. Conception, B. Organization, C. Execution; (2) Statistical Analysis: A. Design, B. Execution, C. Review and Critique; (3) Manuscript preparation: A. Writing of the first draft, B. Review and Critique; L.A.: 1A, 1B, 1C, 2A, 2B, 2C, 3A, 3B M.R.: 1A, 1B, 1C, 2A, 2B, 2C, 3A, 3B A.C.: 1A, 1B, 1C, 2A, 2B, 2C, 3A, 3B M.M.: 1A, 1B, 1C, 2A, 2B, 2C, 3A, 3B Full consent was obtained from the patient before publication. Funding Sources and Conflicts of Interest: The authors report no sources of funding and no conflicts of interest. Financial Disclosures for previous 12 months: The authors declare that there are no disclosures to report. A video accompanying this article is available in the supporting information here. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
• W2180980934 created "2016-06-24" @default.
• W2180980934 creator A5025874193 @default.
• W2180980934 creator A5052760777 @default.
• W2180980934 creator A5084319572 @default.
• W2180980934 creator A5089637495 @default.
• W2180980934 date "2015-11-13" @default.
• W2180980934 modified "2023-10-07" @default.
• W2180980934 title "Ropinirole-Induced Anterocollis in Parkinson's Disease" @default.
• W2180980934 cites W1974426782 @default.
• W2180980934 cites W1980164997 @default.
• W2180980934 cites W1981803073 @default.
• W2180980934 cites W2014472569 @default.
• W2180980934 cites W2035127273 @default.
• W2180980934 cites W2064825579 @default.
• W2180980934 cites W2084772795 @default.
• W2180980934 cites W2102645397 @default.
• W2180980934 cites W2138118192 @default.
• W2180980934 cites W2335643570 @default.
• W2180980934 doi "https://doi.org/10.1002/mdc3.12218" @default.
• W2180980934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6353471" @default.
• W2180980934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30713901" @default.
• W2180980934 hasPublicationYear "2015" @default.
• W2180980934 type Work @default.
• W2180980934 sameAs 2180980934 @default.
• W2180980934 citedByCount "3" @default.
• W2180980934 countsByYear W21809809342016 @default.
• W2180980934 countsByYear W21809809342018 @default.
• W2180980934 countsByYear W21809809342022 @default.
• W2180980934 crossrefType "journal-article" @default.
• W2180980934 hasAuthorship W2180980934A5025874193 @default.
• W2180980934 hasAuthorship W2180980934A5052760777 @default.
• W2180980934 hasAuthorship W2180980934A5084319572 @default.
• W2180980934 hasAuthorship W2180980934A5089637495 @default.
• W2180980934 hasBestOaLocation W21809809341 @default.
• W2180980934 hasConcept C118552586 @default.
• W2180980934 hasConcept C126322002 @default.
• W2180980934 hasConcept C15744967 @default.
• W2180980934 hasConcept C187212893 @default.
• W2180980934 hasConcept C2776132596 @default.
• W2180980934 hasConcept C2777374534 @default.
• W2180980934 hasConcept C2777453868 @default.
• W2180980934 hasConcept C2778559928 @default.
• W2180980934 hasConcept C2779064019 @default.
• W2180980934 hasConcept C2779134260 @default.
• W2180980934 hasConcept C2779424955 @default.
• W2180980934 hasConcept C2779734285 @default.
• W2180980934 hasConcept C2779832395 @default.
• W2180980934 hasConcept C2779989193 @default.
• W2180980934 hasConcept C2780304432 @default.
• W2180980934 hasConcept C2780405171 @default.
• W2180980934 hasConcept C42219234 @default.
• W2180980934 hasConcept C71315377 @default.
• W2180980934 hasConcept C71924100 @default.
• W2180980934 hasConcept C98274493 @default.
• W2180980934 hasConceptScore W2180980934C118552586 @default.
• W2180980934 hasConceptScore W2180980934C126322002 @default.
• W2180980934 hasConceptScore W2180980934C15744967 @default.
• W2180980934 hasConceptScore W2180980934C187212893 @default.
• W2180980934 hasConceptScore W2180980934C2776132596 @default.
• W2180980934 hasConceptScore W2180980934C2777374534 @default.
• W2180980934 hasConceptScore W2180980934C2777453868 @default.
• W2180980934 hasConceptScore W2180980934C2778559928 @default.
• W2180980934 hasConceptScore W2180980934C2779064019 @default.
• W2180980934 hasConceptScore W2180980934C2779134260 @default.
• W2180980934 hasConceptScore W2180980934C2779424955 @default.
• W2180980934 hasConceptScore W2180980934C2779734285 @default.
• W2180980934 hasConceptScore W2180980934C2779832395 @default.
• W2180980934 hasConceptScore W2180980934C2779989193 @default.
• W2180980934 hasConceptScore W2180980934C2780304432 @default.
• W2180980934 hasConceptScore W2180980934C2780405171 @default.
• W2180980934 hasConceptScore W2180980934C42219234 @default.
• W2180980934 hasConceptScore W2180980934C71315377 @default.
• W2180980934 hasConceptScore W2180980934C71924100 @default.
• W2180980934 hasConceptScore W2180980934C98274493 @default.
• W2180980934 hasIssue "1" @default.
• W2180980934 hasLocation W21809809341 @default.
• W2180980934 hasLocation W21809809342 @default.
• W2180980934 hasLocation W21809809343 @default.
• W2180980934 hasLocation W21809809344 @default.
• W2180980934 hasOpenAccess W2180980934 @default.
• W2180980934 hasPrimaryLocation W21809809341 @default.
• W2180980934 hasRelatedWork W140228277 @default.
• W2180980934 hasRelatedWork W1623897717 @default.
• W2180980934 hasRelatedWork W1986579279 @default.
• W2180980934 hasRelatedWork W1998731973 @default.
• W2180980934 hasRelatedWork W2006282889 @default.
• W2180980934 hasRelatedWork W2021763131 @default.
• W2180980934 hasRelatedWork W2028861691 @default.
• W2180980934 hasRelatedWork W2180980934 @default.
• W2180980934 hasRelatedWork W3142053985 @default.
• W2180980934 hasRelatedWork W4211223857 @default.
• W2180980934 hasVolume "3" @default.
• W2180980934 isParatext "false" @default.
• W2180980934 isRetracted "false" @default.
• W2180980934 magId "2180980934" @default.
• W2180980934 workType "article" @default.