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• W2181030173 abstract "This chapter reviews the different options available for the use of ultrasound in the enhancement of fracture healing or in the reactivation of a failed healing process: LIPUS, shock waves and ultrasound-mediated delivery of bioactive molecules, such as growth factors or plasmids. The main emphasis is on LIPUS, or Low Intensity Pulsed Ultrasound, the most widespread and studied technique. LIPUS has pronounced bioeffects on tissue regeneration, while employing intensities within a diagnostic range. The biological response to LIPUS is complex as the response of numerous cell types to this stimulus involves several pathways. Known to-date mechanotransduction pathways involved in cell responses include MAPK and other kinases signaling pathways, gap-junctional intercellular communication, up-regulation and clustering of integrins, involvement of the COX-2/PGE2 and iNOS/NO pathways, and activation of the ATI mechanoreceptor. Mechanisms at the origin of LIPUS biological effects remain intriguing, and analysis is hampered by the diversity of experimental systems used in-vitro. Data point to clear evidence that bioeffects can be modulated by direct and indirect mechanical effects, like acoustic radiation force, acoustic streaming, propagation of surface waves, heat, fluid-flow induced circulation and redistribution of nutrients, oxygen and signaling molecules. One of the future engineering challenge is therefore the design of dedicated experimental set-ups allowing control of these different mechanical phenomena, and to relate them to biological responses. Then, the derivation of an 'acoustic dose' and the cross-calibration of the different experimental systems will be possible. Despite this imperfect knowledge of LIPUS biophysics, the clinical evidence, although most often of low quality, speaks in favor of the clinical use of LIPUS, when the economics of nonunion and the absence of toxicity of this ultrasound technology are taken into account." @default.
• W2181030173 created "2016-06-24" @default.
• W2181030173 creator A5012038333 @default.
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• W2181030173 creator A5076355546 @default.
• W2181030173 creator A5080019211 @default.
• W2181030173 date "2016-01-01" @default.
• W2181030173 modified "2023-10-11" @default.
• W2181030173 title "Stimulation of Bone Repair with Ultrasound" @default.
• W2181030173 cites W117296398 @default.
• W2181030173 cites W1499045550 @default.
• W2181030173 cites W1507752960 @default.
• W2181030173 cites W1512118931 @default.
• W2181030173 cites W1564674105 @default.
• W2181030173 cites W1663371441 @default.
• W2181030173 cites W1674361503 @default.
• W2181030173 cites W1869234208 @default.
• W2181030173 cites W1890394592 @default.
• W2181030173 cites W1963935144 @default.
• W2181030173 cites W1965094170 @default.
• W2181030173 cites W1965161223 @default.
• W2181030173 cites W1966856823 @default.
• W2181030173 cites W1967413924 @default.
• W2181030173 cites W1968465939 @default.
• W2181030173 cites W1968905537 @default.
• W2181030173 cites W1970201788 @default.
• W2181030173 cites W1970293734 @default.
• W2181030173 cites W1971542078 @default.
• W2181030173 cites W1971598681 @default.
• W2181030173 cites W1972512303 @default.
• W2181030173 cites W1973419816 @default.
• W2181030173 cites W1973473260 @default.
• W2181030173 cites W1973829139 @default.
• W2181030173 cites W1974298714 @default.
• W2181030173 cites W1975717142 @default.
• W2181030173 cites W1975991554 @default.
• W2181030173 cites W1976375913 @default.
• W2181030173 cites W1976460018 @default.
• W2181030173 cites W1977956558 @default.
• W2181030173 cites W1979438129 @default.
• W2181030173 cites W1979454586 @default.
• W2181030173 cites W1979722958 @default.
• W2181030173 cites W1981123884 @default.
• W2181030173 cites W1981573530 @default.
• W2181030173 cites W1983187572 @default.
• W2181030173 cites W1983527126 @default.
• W2181030173 cites W1983533664 @default.
• W2181030173 cites W1984028280 @default.
• W2181030173 cites W1984516711 @default.
• W2181030173 cites W1985659604 @default.
• W2181030173 cites W1988194926 @default.
• W2181030173 cites W1990360005 @default.
• W2181030173 cites W1990745892 @default.
• W2181030173 cites W1990973180 @default.
• W2181030173 cites W1991662949 @default.
• W2181030173 cites W1992079743 @default.
• W2181030173 cites W1992105186 @default.
• W2181030173 cites W1993611116 @default.
• W2181030173 cites W1993845544 @default.
• W2181030173 cites W1994579263 @default.
• W2181030173 cites W1996855795 @default.
• W2181030173 cites W1997701240 @default.
• W2181030173 cites W1997812904 @default.
• W2181030173 cites W1998239713 @default.
• W2181030173 cites W1998329693 @default.
• W2181030173 cites W1998588938 @default.
• W2181030173 cites W1998642391 @default.
• W2181030173 cites W2000007601 @default.
• W2181030173 cites W2000292756 @default.
• W2181030173 cites W2000891475 @default.
• W2181030173 cites W2001031044 @default.
• W2181030173 cites W2002287254 @default.
• W2181030173 cites W2002374447 @default.
• W2181030173 cites W2002895237 @default.
• W2181030173 cites W2006699614 @default.
• W2181030173 cites W2007284102 @default.
• W2181030173 cites W2009508208 @default.
• W2181030173 cites W2011043197 @default.
• W2181030173 cites W2013316218 @default.
• W2181030173 cites W2014337155 @default.
• W2181030173 cites W2014840564 @default.
• W2181030173 cites W2015051372 @default.
• W2181030173 cites W2015684215 @default.
• W2181030173 cites W2017568670 @default.
• W2181030173 cites W2017745787 @default.
• W2181030173 cites W2017988486 @default.
• W2181030173 cites W2018281375 @default.
• W2181030173 cites W2018840613 @default.
• W2181030173 cites W2020802601 @default.
• W2181030173 cites W2024332956 @default.
• W2181030173 cites W2024524836 @default.
• W2181030173 cites W2024579642 @default.
• W2181030173 cites W2025046506 @default.
• W2181030173 cites W2026486556 @default.
• W2181030173 cites W2029550402 @default.
• W2181030173 cites W2029790299 @default.
• W2181030173 cites W2029920142 @default.

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