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- W2181034244 abstract "Background: The aim of this study was to evaluate the In vivo antiinflammatory activity of petroleum ether extract of aerial parts of Leucas lavandulaefolia Methods: The anti-inflammatory activity was evaluated by Carrageenan induced rat paw oedema to determine the activity on acute inflammation and Cotton pellet- induced granuloma to determine activity on chronic inflammation. The petroleum ether extract was administered orally at a dose of 100, 200, 400 mg/kg body weight to experimental rat. The anti-inflammatory activity was compared with standard Indomethacin. Results: Results suggested that petroleum ether extract of Leucas lavandulaefolia . aerial parts possess potent anti-inflammatory activity in both the models and the activity was dose dependent. In acute inflammatory model, the effect may be due to inhibition of the release of serotonin and histamine thereby preventing inflammation and also preventing the increased synthesis of prostaglandins in the surroundings of the damaged tissues. In chronic inflammatory model, the effect may be due to inhibition of cellular migration to injured site and accumulation of collagen and mucopolysaccharide. Preliminary phytochemical screening showed presence of triterpenoids and steroids in petroleum ether extract of Leucas lavandulaefolia . aerial parts. Conclusion: The result of present study confirms marked antiinflammatory activity of Leucas lavandulaefolia . The activity may attributed to steroids or triterpenoids in petroleum ether extract of L. lavandulaefolia ." @default.
- W2181034244 created "2016-06-24" @default.
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- W2181034244 date "2013-10-31" @default.
- W2181034244 modified "2023-09-28" @default.
- W2181034244 title "Evaluation of Antiinflammatory Activity of Petroleum Ether Extract from Leucaslavandulaefolia Rees in Albino Rats" @default.
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