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- W2181048693 abstract "The growth factor and cytokine, transforming growth factor-beta (TGF-β), is known for both its tumor suppressive and inductive properties. Its understanding has recently been expanded from epithelial to stromal fibroblastic cells. The observation that the loss of TGF-β responsivity in the stromal fibroblastic cells can initiate neoplastic progression in adjacent epithelial cells from the prostate and the forestomach indicated that TGF-β has a tumor suppressive role not only in responsivity of epithelia but through paracrine signals from the stroma. Interestingly, the transgenic mouse model with the loss of TGF-β receptor type II in the stromal fibroblasts had little overt neoplastic effect on the other tissues. In particular, the stromal cells of the mammary gland expressed some of the same oncogenic growth factors as that of the prostate and the forestomach yet only ductal development was altered. However, when the same mammary stromal cells devoid of TGF-β responsivity was recombined with mammary epithelial cells expressing the polyoma middle T antigen, the mammary tumors that formed had greater infiltration in the circulation. These reports suggest stromal TGF-β responsivity is involved in the initiation, progression and metastasis of cancer in a tissue specific manner." @default.
- W2181048693 created "2016-06-24" @default.
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- W2181048693 date "2008-01-01" @default.
- W2181048693 modified "2023-09-23" @default.
- W2181048693 title "TGF-β Signaling in Fibroblastic Cells and Oncogenesis" @default.
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- W2181048693 doi "https://doi.org/10.1007/978-1-59745-292-2_12" @default.
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