FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181106711> ?p ?o ?g. }

• W2181106711 endingPage "123" @default.
• W2181106711 startingPage "109" @default.
• W2181106711 abstract "The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A polymorphism causing a valine to methionine exchange at position 129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8(+) T cells. It is known that tumors can escape NKG2D-mediated immune surveillance by proteolytic shedding of MICA. Therefore, we investigated whether this polymorphism affects plasma membrane expression (pmMICA) and shedding of MICA. Expression of pmMICA was higher in a panel of tumor (n = 16, P = 0.0699) and melanoma cell lines (n = 13, P = 0.0429) carrying the MICA-129Val/Val genotype. MICA-129Val homozygous melanoma cell lines released more soluble MICA (sMICA) by shedding (P = 0.0015). MICA-129Met or MICA-129Val isoforms differing only in this amino acid were expressed in the MICA-negative melanoma cell line Malme, and clones with similar pmMICA expression intensity were selected. The MICA-129Met clones released more sMICA (P = 0.0006), and a higher proportion of the MICA-129Met than the MICA-129Val variant was retained in intracellular compartments (P = 0.0199). The MICA-129Met clones also expressed more MICA messenger RNA (P = 0.0047). The latter phenotype was also observed in mouse L cells transfected with the MICA expression constructs (P = 0.0212). In conclusion, the MICA-129Met/Val dimorphism affects the expression density of MICA on the plasma membrane. More of the MICA-129Met variants were retained intracellularly. If expressed at the cell surface, the MICA-129Met isoform was more susceptible to shedding. Both processes appear to limit the cell surface expression of MICA-129Met variants that have a high binding avidity to NKG2D." @default.
• W2181106711 created "2016-06-24" @default.
• W2181106711 creator A5005299926 @default.
• W2181106711 creator A5007708890 @default.
• W2181106711 creator A5008709590 @default.
• W2181106711 creator A5043845905 @default.
• W2181106711 creator A5057803955 @default.
• W2181106711 creator A5061762474 @default.
• W2181106711 creator A5077973087 @default.
• W2181106711 creator A5088357947 @default.
• W2181106711 date "2015-11-19" @default.
• W2181106711 modified "2023-10-14" @default.
• W2181106711 title "The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA" @default.
• W2181106711 cites W1495189347 @default.
• W2181106711 cites W1500247462 @default.
• W2181106711 cites W1527114384 @default.
• W2181106711 cites W1532737852 @default.
• W2181106711 cites W1561591140 @default.
• W2181106711 cites W1894510512 @default.
• W2181106711 cites W1926547880 @default.
• W2181106711 cites W1953821950 @default.
• W2181106711 cites W1963731169 @default.
• W2181106711 cites W1964922876 @default.
• W2181106711 cites W1969464492 @default.
• W2181106711 cites W1971404803 @default.
• W2181106711 cites W1974620306 @default.
• W2181106711 cites W1978496119 @default.
• W2181106711 cites W1978714340 @default.
• W2181106711 cites W1982780404 @default.
• W2181106711 cites W1987644268 @default.
• W2181106711 cites W1999341606 @default.
• W2181106711 cites W2000070744 @default.
• W2181106711 cites W2003477720 @default.
• W2181106711 cites W2005314920 @default.
• W2181106711 cites W2005628851 @default.
• W2181106711 cites W2013401565 @default.
• W2181106711 cites W2014240728 @default.
• W2181106711 cites W2021229656 @default.
• W2181106711 cites W2023770746 @default.
• W2181106711 cites W2028876452 @default.
• W2181106711 cites W2032125984 @default.
• W2181106711 cites W2035744694 @default.
• W2181106711 cites W2038184738 @default.
• W2181106711 cites W2041953257 @default.
• W2181106711 cites W2042782719 @default.
• W2181106711 cites W2045752300 @default.
• W2181106711 cites W2047671515 @default.
• W2181106711 cites W2048037791 @default.
• W2181106711 cites W2052095307 @default.
• W2181106711 cites W2053127535 @default.
• W2181106711 cites W2058707044 @default.
• W2181106711 cites W2058708333 @default.
• W2181106711 cites W2060176761 @default.
• W2181106711 cites W2062353391 @default.
• W2181106711 cites W2064920472 @default.
• W2181106711 cites W2071436878 @default.
• W2181106711 cites W2076924907 @default.
• W2181106711 cites W2082450253 @default.
• W2181106711 cites W2091211501 @default.
• W2181106711 cites W2097901628 @default.
• W2181106711 cites W2099183944 @default.
• W2181106711 cites W2100730047 @default.
• W2181106711 cites W2101906420 @default.
• W2181106711 cites W2111515416 @default.
• W2181106711 cites W2119354811 @default.
• W2181106711 cites W2120376881 @default.
• W2181106711 cites W2137782138 @default.
• W2181106711 cites W2139607151 @default.
• W2181106711 cites W2139763899 @default.
• W2181106711 cites W2143561528 @default.
• W2181106711 cites W2146783950 @default.
• W2181106711 cites W2166970460 @default.
• W2181106711 cites W2168895619 @default.
• W2181106711 cites W2169290104 @default.
• W2181106711 cites W2170006155 @default.
• W2181106711 cites W4317639467 @default.
• W2181106711 doi "https://doi.org/10.1007/s00251-015-0884-8" @default.
• W2181106711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4728179" @default.
• W2181106711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26585323" @default.
• W2181106711 hasPublicationYear "2015" @default.
• W2181106711 type Work @default.
• W2181106711 sameAs 2181106711 @default.
• W2181106711 citedByCount "41" @default.
• W2181106711 countsByYear W21811067112016 @default.
• W2181106711 countsByYear W21811067112017 @default.
• W2181106711 countsByYear W21811067112018 @default.
• W2181106711 countsByYear W21811067112019 @default.
• W2181106711 countsByYear W21811067112020 @default.
• W2181106711 countsByYear W21811067112021 @default.
• W2181106711 countsByYear W21811067112023 @default.
• W2181106711 crossrefType "journal-article" @default.
• W2181106711 hasAuthorship W2181106711A5005299926 @default.
• W2181106711 hasAuthorship W2181106711A5007708890 @default.
• W2181106711 hasAuthorship W2181106711A5008709590 @default.
• W2181106711 hasAuthorship W2181106711A5043845905 @default.
• W2181106711 hasAuthorship W2181106711A5057803955 @default.
• W2181106711 hasAuthorship W2181106711A5061762474 @default.
• W2181106711 hasAuthorship W2181106711A5077973087 @default.

• next