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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181163245> ?p ?o ?g. }

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• W2181163245 abstract "The pyrrolidine-5,5-trans-lactam template was used to design small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease displaying potent activity in the replicon cell-based assay. The activity of this series is not dependent upon its chemical reactivity and molecules have been synthesised which combine enhanced biochemical potency with improved plasma stability. Promising initial pharmacokinetic data indicating the potential for further optimisation of this series into low molecular weight, drug-like inhibitors is presented." @default.
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• W2181163245 date "2003-04-01" @default.
• W2181163245 modified "2023-09-26" @default.
• W2181163245 title "The design of potent, non-peptidic inhibitors of hepatitis C protease" @default.
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• W2181163245 doi "https://doi.org/10.1016/s0223-5234(03)00050-3" @default.
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