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- W2181256462 endingPage "30" @default.
- W2181256462 startingPage "23" @default.
- W2181256462 abstract "The proteasome influences cellular homeostasis through the degradation of regulatory proteins, many of which are also involved in disease pathogenesis. In particular, numerous regulatory proteins associated with tumor growth, such as cyclins, cyclin-dependent kinase inhibitors, tumor suppressors, and NF-κB inhibitors are degraded by the proteasome. Proteasome inhibitors can stabilize these regulatory proteins, resulting in the suppression of tumor development and the regulation of immune responses. Thus, proteasome inhibitors are promising candidate antitumor agents and immune-regulatory agents. Bortezomib is the first-in-class proteasome inhibitor approved for the treatment of multiple myeloma. Despite its high efficiency, however, a large proportion of patients do not attain sufficient clinical response due to toxicity and drug resistance. Therefore, the development of new proteasome inhibitors with improved pharmacological properties is needed. Natural products produced by microorganisms are a promising source of such compounds. This review provides an overview of proteasome inhibitors produced by microorganisms, with special focus on inhibitors isolated from actinomycetes." @default.
- W2181256462 created "2016-06-24" @default.
- W2181256462 creator A5064054143 @default.
- W2181256462 creator A5091861377 @default.
- W2181256462 date "2016-08-01" @default.
- W2181256462 modified "2023-10-07" @default.
- W2181256462 title "The therapeutic potential of microbial proteasome inhibitors" @default.
- W2181256462 cites W1570610869 @default.
- W2181256462 cites W1594617739 @default.
- W2181256462 cites W1964114681 @default.
- W2181256462 cites W1964819733 @default.
- W2181256462 cites W1964991829 @default.
- W2181256462 cites W1965187427 @default.
- W2181256462 cites W1965253007 @default.
- W2181256462 cites W1965682834 @default.
- W2181256462 cites W1966704794 @default.
- W2181256462 cites W1967335988 @default.
- W2181256462 cites W1972936800 @default.
- W2181256462 cites W1974010669 @default.
- W2181256462 cites W1977373462 @default.
- W2181256462 cites W1978119971 @default.
- W2181256462 cites W1982358243 @default.
- W2181256462 cites W1985124617 @default.
- W2181256462 cites W1985275612 @default.
- W2181256462 cites W1987583882 @default.
- W2181256462 cites W1988651383 @default.
- W2181256462 cites W1991930087 @default.
- W2181256462 cites W1992978957 @default.
- W2181256462 cites W1996091402 @default.
- W2181256462 cites W1998984578 @default.
- W2181256462 cites W1999042605 @default.
- W2181256462 cites W1999119754 @default.
- W2181256462 cites W2005975820 @default.
- W2181256462 cites W2011457559 @default.
- W2181256462 cites W2016742872 @default.
- W2181256462 cites W2021703849 @default.
- W2181256462 cites W2026642838 @default.
- W2181256462 cites W2028038380 @default.
- W2181256462 cites W2032891189 @default.
- W2181256462 cites W2033944464 @default.
- W2181256462 cites W2037825770 @default.
- W2181256462 cites W2038430270 @default.
- W2181256462 cites W2039422688 @default.
- W2181256462 cites W2039444033 @default.
- W2181256462 cites W2045027261 @default.
- W2181256462 cites W2046364391 @default.
- W2181256462 cites W2047650149 @default.
- W2181256462 cites W2049399172 @default.
- W2181256462 cites W2051458654 @default.
- W2181256462 cites W2052840623 @default.
- W2181256462 cites W2061194648 @default.
- W2181256462 cites W2061358885 @default.
- W2181256462 cites W2062653186 @default.
- W2181256462 cites W2063035249 @default.
- W2181256462 cites W2066284211 @default.
- W2181256462 cites W2066875565 @default.
- W2181256462 cites W2067482979 @default.
- W2181256462 cites W2067653691 @default.
- W2181256462 cites W2072714194 @default.
- W2181256462 cites W2074051660 @default.
- W2181256462 cites W2074423119 @default.
- W2181256462 cites W2074624442 @default.
- W2181256462 cites W2084843323 @default.
- W2181256462 cites W2085187792 @default.
- W2181256462 cites W2091403769 @default.
- W2181256462 cites W2095499213 @default.
- W2181256462 cites W2101759139 @default.
- W2181256462 cites W2103185055 @default.
- W2181256462 cites W2106578289 @default.
- W2181256462 cites W2106692847 @default.
- W2181256462 cites W2107154392 @default.
- W2181256462 cites W2108235071 @default.
- W2181256462 cites W2108608653 @default.
- W2181256462 cites W2109371953 @default.
- W2181256462 cites W2110385671 @default.
- W2181256462 cites W2112190271 @default.
- W2181256462 cites W2115133998 @default.
- W2181256462 cites W2115687796 @default.
- W2181256462 cites W2116588827 @default.
- W2181256462 cites W2118820477 @default.
- W2181256462 cites W2120590293 @default.
- W2181256462 cites W2121760719 @default.
- W2181256462 cites W2123077018 @default.
- W2181256462 cites W2123322767 @default.
- W2181256462 cites W2124560610 @default.
- W2181256462 cites W2126267349 @default.
- W2181256462 cites W2129937834 @default.
- W2181256462 cites W2132485651 @default.
- W2181256462 cites W2135481148 @default.
- W2181256462 cites W2142316927 @default.
- W2181256462 cites W2145412346 @default.
- W2181256462 cites W2150168624 @default.
- W2181256462 cites W2154343997 @default.
- W2181256462 cites W2159831275 @default.
- W2181256462 cites W2162832511 @default.
- W2181256462 cites W2163495162 @default.
- W2181256462 cites W2163679078 @default.
- W2181256462 cites W2164028372 @default.