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- W2181277827 abstract "IL-33, a new member of the IL-1 cytokine family, may be atheroprotective via induction of a Th1-to-Th2 immunologic switch. However, to date, the role of IL-33 in cardiovascular disease remains unclear. The purpose of this study is to assess the level of IL-33 in atopic patients and its effect on the expression of proteins involved in cholesterol transport. Plasma IL-33 was measured by ELISA (GenWay Biotech) in 10 healthy volunteers (NHC) and 10 atopic patients (AP). THP-1 human macrophages were exposed to 10% NHC or AP plasma (18 hours). mRNA was isolated and reverse transcribed. Message levels were quantified by QRT-PCR for the efflux proteins ABCA1 and ABCG1 and the scavenger receptors CD36 and SR-A1. Expression was normalized to the housekeeping gene, GAPDH. IL-33 levels in AP ranged from 2-500ng/ml, significantly higher than NHC (P<0.01). Exposure of THP-1 macrophages to AP plasma downregulated ABCA1 and ABCG1 mRNA by 34.0±12.5% and 51.0±12.5%, respectively (n=3, P<0.01). Plasma from AP with lowest level of IL-33 (<10ng/ml) correlated with the lowest mRNA levels of ABCA1 and ABCG1. CD36 was upregulated to 143.4±36.5% (P<0.01, n=3). The AP with the highest IL-33 level (500 ng/mL) correlated with highest CD36 mRNA. SR-A1 was not affected by AP plasma. Plasma from AP induces changes in cholesterol flux gene expression, potentially reflecting a pro-atherogenic state. Given the wide variety of cellular responses regulated by IL-33, further investigation with a larger atopic sample size will allow us to clarify the role of IL-33 in cholesterol homeostasis in these patients." @default.
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- W2181277827 date "2013-02-01" @default.
- W2181277827 modified "2023-09-27" @default.
- W2181277827 title "The Role of IL-33 in Allergic Disease and Atherosclerosis" @default.
- W2181277827 doi "https://doi.org/10.1016/j.jaci.2012.12.849" @default.
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