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• W2181308461 abstract "Lysosomal destabilization is a critical event not only for the organelle but also for living cells. However, what factors can affect lysosomal stability is not fully studied. In this work, the effects of phosphatidic acid (PA) on the lysosomal integrity were investigated. Through the measurements of lysosomal beta-hexosaminidase free activity, intralysosomal pH, leakage of lysosomal protons and lysosomal latency loss in hypotonic sucrose medium, we established that PA could increase the lysosomal permeability to K+ and H+, and enhance the lysosomal osmotic sensitivity. Treatment of lysosomes with PA promoted entry of K+ into the organelle via K+/H+ exchange, which could produce osmotic stresses and osmotically destabilize the lysosomes. In addition, PA-induced increase in the lysosomal osmotic sensitivity caused the lysosomes to become more liable to destabilization in osmotic shocks. The results suggest that PA may play a role in the lysosomal destabilization." @default.
• W2181308461 created "2016-06-24" @default.
• W2181308461 creator A5000973594 @default.
• W2181308461 creator A5088255846 @default.
• W2181308461 date "2006-06-01" @default.
• W2181308461 modified "2023-09-23" @default.
• W2181308461 title "Phosphatidic acid osmotically destabilizes lysosomes through increased permeability to K+ and H+." @default.
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• W2181308461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16917129" @default.
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