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- W2181309505 abstract "The tear fluid is a water solution rich in lipids (fat molecules). It disinfects the surface of the eye and protects it from drying. The lipids of the tear fluid form a monolayer between the air and the water solution, preventing the vaporization of water molecules from the surface of the eye. If the lipid composition of tear fluid is abnormal, for example due to long days in front of computer, so called dry eyes can result. Dry eyes can be treated with liquid mixtures which balance the lipid composition of the eye, but those products are often not very effective. To improve the effectivity of these mixtures the properties of the lipid layer between the eye surface and air needs to be investigated. There are only a few computational models of lipid layers in air-water interface [1]. Here we present a simulation of the lipid layer of tear fluid, constructed from experimental lipid composition and modelled with Martini coarse grained force field, designed especially for simulations of lipids and other biomolecules. The simulations with Gromacs software allow us to elucidate structural and dynamical properties of the tear fluid systems, and in particular the compression isotherms, that describe the equation of state for these complex lipid systems. The results will be discussed in detail. This project is being carried out together with our experimental collaborators (J. Holopainen et al.)" @default.
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- W2181309505 date "2007-01-01" @default.
- W2181309505 modified "2023-09-27" @default.
- W2181309505 title "THE STRUCTURE OF HUMAN TEAR FLUID AT THE AIR-WATER INTERFACE - A COMPUTATIONAL STUDY" @default.
- W2181309505 hasPublicationYear "2007" @default.
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