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• W2181330332 abstract "Tubulin isotype distribution may play a role in the development of anti-cancer anti-tubulin drug resistance as well as in drug efficacy and specificity. Stepwise selection was used to establish non-small cell lung carcinoma (NSCLC) H460 cells resistant to combretastatin A-4 (CA4), paclitaxel or vinblastine. The results demonstrated that the rate of CA4 drug resistance development was slower than that for paclitaxel. Western analysis demonstrated alterations in total beta-tubulin and classes I, III and IV tubulin isotypes among the resistant H460 cell lines. Class III beta-tubulin was significantly altered in all resistant cell lines. Cells resistant to paclitaxel, a structural stabilizer of microtubules, exhibited an increased expression while cells resistant to CA-4 and vinblastine, structural destabilizers of tubulin, demonstrated a reduction of the same isotype. To our knowledge, this is the first demonstration of resistance development and of the corresponding tubulin isotype response for the combretastatins." @default.
• W2181330332 created "2016-06-24" @default.
• W2181330332 creator A5041696120 @default.
• W2181330332 creator A5061811618 @default.
• W2181330332 creator A5061939858 @default.
• W2181330332 date "2005-11-29" @default.
• W2181330332 modified "2023-09-25" @default.
• W2181330332 title "Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression." @default.
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• W2181330332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16309172" @default.
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