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- W2181341067 abstract "The binding constants of substrate, inhibitors and coenzymes to native Lactobacillus casei dihydrofolate reductase and to the enzyme modified (at Trp-21) by N-bromosuccinimide have been determined using fluorimetric and spectrophotometric methods. The modification leads to only modest decreases (factors of 2-4) in the binding of substrate or substrate analogues, but the effects of coenzyme binding are much larger. The binding of NADPH is decreased by a factor of 200, but that of NADP+ by only a factor of 4, indicating a clear difference in their mode of interaction with the enzyme. The nature of this difference is discussed in the light of crystallographic and n.m.r. studies of the enzyme." @default.
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- W2181341067 date "1980-05-01" @default.
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- W2181341067 title "The effects of modification with <i>N</i>-bromosuccinimide on the binding of ligands to dihydrofolate reductase" @default.
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- W2181341067 doi "https://doi.org/10.1042/bj1870501" @default.
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