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- W2181378203 abstract "General Remarks ntracranial hemorrhage (ICH)is a frequent indication for emergent neuroimaging. To understand the appearance of clots on CT and MR it is mandatory to know some details of clot formation. Initially, an intracerebral hematoma is composed of 95% to 98% oxygensaturated hemoglobin, mainly containing erythrocytes. Over the first 4-6 hours the protein clot retracts, still containing intact biconcave red blood cells with oxygenated hemoglobin. During the next 48 hours the RBC shrinks and hemoglobin desaturation occurs. During this period the hematoma contains predominantly deoxygenated intracellular (remember: the RBCs are still intact!) hemoglobin. In the early subacute phase (a few days after the initial hemorrhage) oxidative denaturation of the hemoglobin progresses and deoxyhemoglobin is gradually converted to methemoglobin (MetHb). These changes first occur around the periphery of the hematoma and then progress centrally. RBCs continuously lyse and release MetHb into the extracellular space. After that the hematoma starts to shrink and finally there is a slitlike cavity, containing CSF-like fluid and – as a long-standing marker for the bleeding – ferritin- and hemosiderin- laden macrophages." @default.
- W2181378203 created "2016-06-24" @default.
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- W2181378203 date "2007-01-01" @default.
- W2181378203 modified "2023-09-27" @default.
- W2181378203 title "Imaging of Intracranial Hemorrhage: A Review Article This review gives an overview about pathophysiology, pathology and imaging findings in pa- tients with intracranial hemorrhage and illustrates typical and common findings." @default.
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