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• W2181393310 abstract "The objective of the present investigation was to evaluate the in vivo antioxidant and lipid peroxidation effect of various extracts from whole plant of Ionidium suffruticosum (Ging.) in rat fed with high fat diet. Various extracts (Petroleum ether, Ethyl acetate and Methanol) of Ionidium suffruticosum (200 mg/kg body weight) was administered orally to rats fed with high-fat diet (HFD) daily for 9 weeks and the tissue (liver, heart and aorta) samples were collected at the end of experimental period. High fat diet rats showed significantly (P<0.001) reduced the levels of tissues enzymatic antioxidant and non enzymatic antioxidant (Glutathione). The level of thiobarbituric acid reactive substances (TBARS) are elevated in HFD rats (group II) when compared with control rats (group I). After administration of methanolic extract of Ionidium suffruticosum in high fat diet rats were showed significantly (P<0.001) increased the levels of antioxidant enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione reductase (GR) and incresed the level of non enzymatic antioxidant Glutathione (GSH) when compared with HFD rats (Group II). The methanolic extract of Ionidium suffruticosum in high fat diet rats were found reduced the concentration of TBARS than that of HFD rats (group II). Similar result was not observed in other two extract treatment groups. Based on the results, we concluded that the methanolic extract of Ionidium suffruticosum is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses." @default.
• W2181393310 created "2016-06-24" @default.
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• W2181393310 date "2012-01-01" @default.
• W2181393310 modified "2023-09-27" @default.
• W2181393310 title "IN-VIVO ANTIOXIDANT AND LIPID PEROXIDATION EFFECT OF WHOLE PLANT OF IONIDIUM SUFFRUTICOSUM (Ging.) IN RATS FED WITH HIGH FAT DIET" @default.
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