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- W2181435443 abstract "The term bioavailability refers to that proportion of a drug which reaches the systemic circulation unchanged after a particular route of administration. To produce a clinical response, a drug must achieve an effective concentration at its site of action, which must be maintained for an adequate length of time. For orally administered systemic agents, this involves the transfer of the drug from the gut to the systemic circulation. In order to achieve this, the drug must first enter solution, and then pass into the portal blood-i.e. it must undergo absorption. Among all the routes of drug administration the oral route administration of drugs is convenient, and linking drug doses to daily routines such as meal times can improve compliance. However, inter-individual variation in drug response, particularly following oral administration, has long been a problem. Since this variation can result in therapeutic failure or drug toxicity, the 'art of bespoke prescribing' remains a major goal of clinical pharmacology." @default.
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- W2181435443 date "2014-01-01" @default.
- W2181435443 modified "2023-09-24" @default.
- W2181435443 title "ADVERSE EVENT REPORTING FOR A FOOD EFFECT BIOAVAILABILITY STUDY OF ROXITHROMYCIN" @default.
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