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- W2181440616 abstract "software. Results: Without sCD40L,the mean thrombus volume (±SD) was 8,412±1,472µm3 after 5 min and 34,922±4,776µm3 after 10 min. Addition of sCD40L caused a significant increase in the thrombus volume, i.e. 20,641±6,604µm3 (5 min) and 64,131±13,840µm3 (10 min) at 1 ng/ml or 31,091±15,740µm3 (5 min) and 69,707±35,373µm3 (10 min) at 5 ng/ml, respectively.At 10 to 20 ng/ml of sCD40L, thrombus volumes were only marginally increased, i.e. 12,920±1,808µm3 (5 min) and 43,785±5,401µm3 (10 min), and 100 ng/ml of sCD40L did not show any significant effect on thrombus formation. Conclusion: Under arterial flow conditions, platelet thrombus formation shows a sCD40L concentration-dependent growth. Clinically relevant levels of sCD40L (1‐5 ng/ml) increase platelet thrombus volumes, while higher concentrations of sCD40L do not affect thrombus growth.These in vitro data confirm the prothrombotic effects of sCD40L and indicate that sCD40L may modulate arterial thrombus formation in vivo." @default.
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- W2181440616 date "2009-01-01" @default.
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- W2181440616 title "Human platelet granule secretion induced by thrombin and collagen is differentially modulated by integrins: Platelet function of a patient with LADIII syndrome" @default.
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