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- W2181467668 abstract "Klebsiella pneumoniae is one of the common gram-negative bacteria causin g community and hospital acquired infections. Multi d rug resistant K. pneumoniae has been a persistent threat; this compels the search f or alternate antibacterial agents. Chitosan, manuka honey and chlorophyll have received much attention after extensive research was conducted to investigate antibacterial properties and applications in the field of biomedicine and pharmaceutics. A prelimina ry study was undertaken to compare the antibacterial effect of chitosan, manuk a honey and chlorophyll against K. pneumoniae. Stock solutions of chitosan, manuka honey and chlor ophyll were prepared at 1% w/v concentration. The primary methods used in this investigation were minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC). From the study, it was shown that chitosan exhibited MIC breakpoint at 175µl/ml and MBC at 425µl/ml. against K. pneumoniae. Manuka honey and chlorophyll however, did not show significant antib acterial effect at 1% w/v due to the degree of dilution but were found to be effecti ve at 100% w/v. Chitosan demonstrated promising results to use as the altern ate antibacterial agent against multi-drug resistant K. pneumoniae. Chitosan can also be incorporated in hand gloves, coating agent on medical equipments and invasive devices to discourage the adherence of K. pneumoniae ." @default.
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- W2181467668 date "2011-01-01" @default.
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- W2181467668 title "Antibacterial Efficacy of Chitosan, Manuka Honey and Chlorophyll against Klebsiella Pneumoniae" @default.
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