Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181486640> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2181486640 abstract "Anxiety is a psychological and physiological disorder. It consists of cognitive, somatic and behavioral components. It is characterized by an unpleasant feeling that is typically associated with uneasiness, fear or worry. The primary objective of the study was to compare anxiolytic activities of sodium valproate, gabapentin, pregabalin and alprazolam in rats. Standard experimental models like elevated plus maze and Open field test were used to assess anxiolytic activity. Total 30 rats divided into five groups and six in each (n=6). Group1 rats received gum acacia 10 ml/kg as control, and Gr. 2, 3, 4, 5 received test drugs, gabapentin 50 mg/kg , pregabalin 1.8 mg/kg , sodium valproate 150 mg/kg, alprazolam 0.08 mg/kg, daily, orally, for 10days respectively. The time spent, number of entries, rears in arms of elevated plus maze and number of entries, time spent in central and peripheral squares in open field test were observed. All test drug treated rats showed significant anxiolytic activity by decreasing the time spent in closed arm and increasing in open arm as compared to control. However, increase or decrease in time spent was not comparable among test drug groups. In open field, time spent by rats treated with alprazolam, sodium valproate, gabapentin, pregabalin was increased in the center but decreased in the periphery as compared to control. Thus alprazolam, sodium valproate, gabapentin, pregabalin were found to produce anti-anxiety in rats compared to control. However, anxiolytic actions were not comparable between test drug treated rats." @default.
- W2181486640 created "2016-06-24" @default.
- W2181486640 creator A5016932151 @default.
- W2181486640 creator A5043347047 @default.
- W2181486640 creator A5063000831 @default.
- W2181486640 creator A5079461619 @default.
- W2181486640 creator A5087689674 @default.
- W2181486640 date "2015-01-01" @default.
- W2181486640 modified "2023-09-27" @default.
- W2181486640 title "Anxiolytic activity of gabapentin, pregabalin, sodium valproate and alprazolam in wistar albino rats - a comparative study" @default.
- W2181486640 cites W1877933911 @default.
- W2181486640 cites W1964160578 @default.
- W2181486640 cites W1990580330 @default.
- W2181486640 cites W2026151186 @default.
- W2181486640 cites W2026981835 @default.
- W2181486640 cites W2041561931 @default.
- W2181486640 cites W2055523882 @default.
- W2181486640 cites W2248505945 @default.
- W2181486640 cites W2400553812 @default.
- W2181486640 hasPublicationYear "2015" @default.
- W2181486640 type Work @default.
- W2181486640 sameAs 2181486640 @default.
- W2181486640 citedByCount "0" @default.
- W2181486640 crossrefType "journal-article" @default.
- W2181486640 hasAuthorship W2181486640A5016932151 @default.
- W2181486640 hasAuthorship W2181486640A5043347047 @default.
- W2181486640 hasAuthorship W2181486640A5063000831 @default.
- W2181486640 hasAuthorship W2181486640A5079461619 @default.
- W2181486640 hasAuthorship W2181486640A5087689674 @default.
- W2181486640 hasConcept C118552586 @default.
- W2181486640 hasConcept C126322002 @default.
- W2181486640 hasConcept C142724271 @default.
- W2181486640 hasConcept C173586616 @default.
- W2181486640 hasConcept C204787440 @default.
- W2181486640 hasConcept C2775858608 @default.
- W2181486640 hasConcept C2776175493 @default.
- W2181486640 hasConcept C2776468701 @default.
- W2181486640 hasConcept C2776608144 @default.
- W2181486640 hasConcept C2777196872 @default.
- W2181486640 hasConcept C2777765862 @default.
- W2181486640 hasConcept C2778186239 @default.
- W2181486640 hasConcept C2779085643 @default.
- W2181486640 hasConcept C42219234 @default.
- W2181486640 hasConcept C558461103 @default.
- W2181486640 hasConcept C71924100 @default.
- W2181486640 hasConcept C98274493 @default.
- W2181486640 hasConceptScore W2181486640C118552586 @default.
- W2181486640 hasConceptScore W2181486640C126322002 @default.
- W2181486640 hasConceptScore W2181486640C142724271 @default.
- W2181486640 hasConceptScore W2181486640C173586616 @default.
- W2181486640 hasConceptScore W2181486640C204787440 @default.
- W2181486640 hasConceptScore W2181486640C2775858608 @default.
- W2181486640 hasConceptScore W2181486640C2776175493 @default.
- W2181486640 hasConceptScore W2181486640C2776468701 @default.
- W2181486640 hasConceptScore W2181486640C2776608144 @default.
- W2181486640 hasConceptScore W2181486640C2777196872 @default.
- W2181486640 hasConceptScore W2181486640C2777765862 @default.
- W2181486640 hasConceptScore W2181486640C2778186239 @default.
- W2181486640 hasConceptScore W2181486640C2779085643 @default.
- W2181486640 hasConceptScore W2181486640C42219234 @default.
- W2181486640 hasConceptScore W2181486640C558461103 @default.
- W2181486640 hasConceptScore W2181486640C71924100 @default.
- W2181486640 hasConceptScore W2181486640C98274493 @default.
- W2181486640 hasLocation W21814866401 @default.
- W2181486640 hasOpenAccess W2181486640 @default.
- W2181486640 hasPrimaryLocation W21814866401 @default.
- W2181486640 hasRelatedWork W162266991 @default.
- W2181486640 hasRelatedWork W1920760058 @default.
- W2181486640 hasRelatedWork W1966847337 @default.
- W2181486640 hasRelatedWork W2048878805 @default.
- W2181486640 hasRelatedWork W2050057350 @default.
- W2181486640 hasRelatedWork W2094472817 @default.
- W2181486640 hasRelatedWork W2127410279 @default.
- W2181486640 hasRelatedWork W2168265602 @default.
- W2181486640 hasRelatedWork W2171453588 @default.
- W2181486640 hasRelatedWork W2259604282 @default.
- W2181486640 hasRelatedWork W2275549044 @default.
- W2181486640 hasRelatedWork W2433994651 @default.
- W2181486640 hasRelatedWork W2434200005 @default.
- W2181486640 hasRelatedWork W2434937513 @default.
- W2181486640 hasRelatedWork W2496929263 @default.
- W2181486640 hasRelatedWork W2517596706 @default.
- W2181486640 hasRelatedWork W2605241133 @default.
- W2181486640 hasRelatedWork W3126714838 @default.
- W2181486640 hasRelatedWork W2182368563 @default.
- W2181486640 hasRelatedWork W2992510852 @default.
- W2181486640 isParatext "false" @default.
- W2181486640 isRetracted "false" @default.
- W2181486640 magId "2181486640" @default.
- W2181486640 workType "article" @default.