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- W21815037 abstract "Aspergillus species and dermatophytes are medically important fungi (Bodey and Vartivarian, 1989; Grappel et al., 1974). Both fungal groups produce exocellular antigens containing galactomannan molecules. Chemical characterization of these polysaccharidic antigens remain incomplete. However, the presence of non-reducing galactofuranose end units have been demonstrated unequivocally in both Aspergillus and dermatophyte species (Latgé et al., chapter 11; de Haan et al.,chapter 28). Polyclonal antibodies have been produced against Aspergillus galactomannans for the detection of antigens either in serum of patients with invasive aspergillosis or in foodstuffs, contaminated by fungi (Bennett et al., 1985; Notermans et al.,1988; Banks et al., 1990). These studies have shown that the galactofuran side chains of the galactomannan are immunodominant. Cross-reaction has been observed among these antisera and other fungi, including dermatophytes. Such cross-reaction may be due to structural relatedness of the polysaccharides of different fungal species but also to the polyclonal character of these antisera. Therefore, monoclonal antibodies (MAbs), directed against a single epitope, would be more usçful. A recent paper by Ste-Marie et al. (1990) describes two murine MAbs which react to Aspergillus galactomannan epitopes, which cross-reacted with fungi from other genera. In this paper we describe the production of rat MAbs against Aspergillus galactomannan and the initial characterization of rat MAbs against exocellular antigens of the dermatophyte Trichophyton rubrum." @default.
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- W21815037 date "1991-01-01" @default.
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- W21815037 title "Rat Monoclonal Antibodies Against Exocellular Carbohydrate Antigens of Aspergillus and Dermatophytes" @default.
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- W21815037 doi "https://doi.org/10.1007/978-3-642-76074-7_14" @default.
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