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• W2181507124 startingPage "L893" @default.
• W2181507124 abstract "Pulmonary surfactant is secreted via exocytosis of lamellar bodies (LBs) by alveolar type II cells. Here we analyzed the dependence of LB exocytosis on intracellular Ca 2+ concentration ([Ca 2+ ] i ). In fura 2-loaded cells, [Ca 2+ ] i was selectively elevated by flash photolysis of a cell-permeant caged Ca 2+ compound ( o-nitrophenyl EGTA-AM) or by gradually enhancing cellular Ca 2+ influx. Simultaneously, surfactant secretion by single cells was analyzed with the fluorescent dye FM 1-43, enabling detection of exocytotic events with a high temporal resolution (T. Haller, J. Ortmayr, F. Friedrich, H. Volkl, and P. Dietl. Proc. Natl. Acad. Sci. USA 95: 1579–1584, 1998). Exocytosis was initiated at a threshold concentration near 320 nmol/l with both instantaneous or gradual [Ca 2+ ] i elevations. The exocytotic response to flash photolysis was highest during the first minute after the rise in [Ca 2+ ] i and thus almost identical to purinoceptor stimulation by ATP. Correspondingly, the effects of ATP on initial secretion could be sufficiently explained by its ability to mobilize Ca 2+ . This was further demonstrated by the fact that exocytosis is significantly blocked by suppression of the ATP-induced Ca 2+ signal below ∼300 nmol/l. Our results suggest a highly Ca 2+ -sensitive step in LB exocytosis." @default.
• W2181507124 created "2016-06-24" @default.
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• W2181507124 date "1999-11-01" @default.
• W2181507124 modified "2023-10-15" @default.
• W2181507124 title "Threshold calcium levels for lamellar body exocytosis in type II pneumocytes" @default.
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• W2181507124 doi "https://doi.org/10.1152/ajplung.1999.277.5.l893" @default.
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