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• W2181509675 abstract "Premixes for medicated feedstuffs are considered to be veterinary medicinal products (VMPs) prepared in advance with a view to the subsequent manufacture of medicated feedstuffs. Medicated feedstuffs should be prepared only from market authorized premixes and premixes for medicated feedstuffs can be used only as prescribed medicines. Apart from active substances, premixes contain carriers which have a role in the homogenization of medicated feedstuffs. Wheat bran as a carrier may be a source of different, potentially harmful or toxic substances e.g. afl atoxin. In our study, 15 different batches of premixes with a wheat bran component were tested for afl atoxin B 1 (AFB 1 ) by means of an enzyme-linked immunosorbent assay (ELISA). The samples tested showed contamination with AFB1 ranging from 1.5 to 35 ng/g (mean = 18.79 ng/g). However, no correlation between AFB 1 levels and the month of collection or season of production was observed. Considering the composition of the premix, the only possible source of contamination with AFB 1 was wheat bran. Contamination probably occurred before the production of the premix, probably in the fi eld or during storage. Concentrations of active substances and citric acid (a neutralising agent for mycotoxins) were in accordance with the producer's declaration. Our discovery of AFB1 in the tested premixes was in contravention of the defi nition and primary role of veterinary medicinal products. In this study, we would like to highlight the need for monitoring raw materials of biological origin for premix production. Even though carriers are not pharmacologically active substances, an effi cient method for controlling potential contaminants such as mycotoxins or their toxic components should be proposed, with the aim of protecting animal health, consumers, employees and end-users in the production of veterinary medicinal products." @default.
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• W2181509675 date "2012-03-08" @default.
• W2181509675 modified "2023-09-26" @default.
• W2181509675 title "Aflatoxin B1 in wheat bran containing premix." @default.
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