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• W2181537380 endingPage "2893" @default.
• W2181537380 startingPage "2885" @default.
• W2181537380 abstract "During mitosis of the Drosophila cortical syncytial divisions, actin-based membrane furrows separate adjacent spindles. Our genetic analysis indicates that the centrosomal protein Nuf is specifically required for recruitment of components to the furrows and the membrane-associated protein Dah is primarily required for the inward invagination of the furrow membrane. Recruitment of actin, anillin and peanut to the furrows occurs normally in dah-derived embryos. However, subsequent invagination of the furrows fails in dah-derived embryos and the septins become dispersed throughout the cytoplasm. This indicates that stable septin localization requires Dah-mediated furrow invagination. Close examination of actin and Dah localization in wild-type embryos reveals that they associate in adjacent particles during interphase and co-localize in the invaginating furrows during prophase and metaphase. We show that the Nuf centrosomal protein is required for recruiting the membrane-associated protein Dah to the furrows. In nuf-mutant embryos, much of the Dah does not reach the furrows and remains in a punctate distribution. This suggests that Dah is recruited to the furrows in vesicles and that the recruiting step is disrupted in nuf mutants. These studies lead to a model in which the centrosomes play an important role in the transport of membrane-associated proteins and other components to the developing furrows." @default.
• W2181537380 created "2016-06-24" @default.
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• W2181537380 date "1999-09-01" @default.
• W2181537380 modified "2023-10-09" @default.
• W2181537380 title "The <i>Drosophila</i> centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo" @default.
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• W2181537380 doi "https://doi.org/10.1242/jcs.112.17.2885" @default.
• W2181537380 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10444383" @default.
• W2181537380 hasPublicationYear "1999" @default.
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