Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181573672> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2181573672 abstract "W. E. Hull, M. Wolf, S. Heiland, U. Bauder-Wuest, M. Eisenhut Central Spectroscopy, German Cancer Research Center (DKFZ), Heidelberg, Germany, Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Heidelberg, Germany, Experimental Neuroradiology, University of Heidelberg, Heidelberg, Germany Introduction Conventional paramagnetic MRI contrast agents such as [Gd(DTPA)(H2O)] 2– (Magnevist) exhibit low tissue specificity. Therefore, increasing efforts are being made to develop targeted agents [1] through conjugation with monoclonal antibodies [2] or modification to achieve high affinity for a tumor-specific cell-surface protein, for example [3]. An alternative strategy is to employ intracellular uptake to “label” the cells of interest. This requires, for detectable T1-weighted MRI contrast, internalization of 10 7 10 Gd(III) complexes (0.017 0.17 fmol) per cell. However, clinical contrast agents do not readily enter cells passively or via active transport. It has been shown that ligand sidechains containing alkylamine or polyamine moieties enhance the intracellular uptake of technetium complexes or radioiodinated benzamides for melanoma scintigraphy [4,5], presumably by active transport via polyamine transporter proteins. Since proliferating tumor cells are expected to have enhanced polyamine uptake, our strategy was to develop a new class of polyamine-derivatized Gd-DTPA complexes with high intracellular tumor uptake and retention." @default.
- W2181573672 created "2016-06-24" @default.
- W2181573672 creator A5035092573 @default.
- W2181573672 creator A5036640000 @default.
- W2181573672 creator A5051876759 @default.
- W2181573672 creator A5075398671 @default.
- W2181573672 creator A5079482117 @default.
- W2181573672 date "2006-01-01" @default.
- W2181573672 modified "2023-09-27" @default.
- W2181573672 title "Polyamine-substituted Gd-DTPA: intracellular, tumor-selective, high-retention MRI contrast agents" @default.
- W2181573672 hasPublicationYear "2006" @default.
- W2181573672 type Work @default.
- W2181573672 sameAs 2181573672 @default.
- W2181573672 citedByCount "0" @default.
- W2181573672 crossrefType "journal-article" @default.
- W2181573672 hasAuthorship W2181573672A5035092573 @default.
- W2181573672 hasAuthorship W2181573672A5036640000 @default.
- W2181573672 hasAuthorship W2181573672A5051876759 @default.
- W2181573672 hasAuthorship W2181573672A5075398671 @default.
- W2181573672 hasAuthorship W2181573672A5079482117 @default.
- W2181573672 hasConcept C116569031 @default.
- W2181573672 hasConcept C12554922 @default.
- W2181573672 hasConcept C139770010 @default.
- W2181573672 hasConcept C1491633281 @default.
- W2181573672 hasConcept C170493617 @default.
- W2181573672 hasConcept C185592680 @default.
- W2181573672 hasConcept C2780115381 @default.
- W2181573672 hasConcept C502942594 @default.
- W2181573672 hasConcept C55493867 @default.
- W2181573672 hasConcept C79879829 @default.
- W2181573672 hasConcept C86803240 @default.
- W2181573672 hasConceptScore W2181573672C116569031 @default.
- W2181573672 hasConceptScore W2181573672C12554922 @default.
- W2181573672 hasConceptScore W2181573672C139770010 @default.
- W2181573672 hasConceptScore W2181573672C1491633281 @default.
- W2181573672 hasConceptScore W2181573672C170493617 @default.
- W2181573672 hasConceptScore W2181573672C185592680 @default.
- W2181573672 hasConceptScore W2181573672C2780115381 @default.
- W2181573672 hasConceptScore W2181573672C502942594 @default.
- W2181573672 hasConceptScore W2181573672C55493867 @default.
- W2181573672 hasConceptScore W2181573672C79879829 @default.
- W2181573672 hasConceptScore W2181573672C86803240 @default.
- W2181573672 hasLocation W21815736721 @default.
- W2181573672 hasOpenAccess W2181573672 @default.
- W2181573672 hasPrimaryLocation W21815736721 @default.
- W2181573672 hasRelatedWork W1519971674 @default.
- W2181573672 hasRelatedWork W1969101896 @default.
- W2181573672 hasRelatedWork W1978039785 @default.
- W2181573672 hasRelatedWork W2006687439 @default.
- W2181573672 hasRelatedWork W2016132243 @default.
- W2181573672 hasRelatedWork W2026186063 @default.
- W2181573672 hasRelatedWork W2030324186 @default.
- W2181573672 hasRelatedWork W2039572832 @default.
- W2181573672 hasRelatedWork W2062115213 @default.
- W2181573672 hasRelatedWork W2066160133 @default.
- W2181573672 hasRelatedWork W2066620431 @default.
- W2181573672 hasRelatedWork W2074251226 @default.
- W2181573672 hasRelatedWork W2086495534 @default.
- W2181573672 hasRelatedWork W2315187861 @default.
- W2181573672 hasRelatedWork W2334099161 @default.
- W2181573672 hasRelatedWork W2397150638 @default.
- W2181573672 hasRelatedWork W2398129404 @default.
- W2181573672 hasRelatedWork W2473834897 @default.
- W2181573672 hasRelatedWork W2802867384 @default.
- W2181573672 hasRelatedWork W2888187056 @default.
- W2181573672 isParatext "false" @default.
- W2181573672 isRetracted "false" @default.
- W2181573672 magId "2181573672" @default.
- W2181573672 workType "article" @default.