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• W2181587923 startingPage "877" @default.
• W2181587923 abstract "ABSTRACT While the treadmilling and retrograde flow of F-actin are believed to be responsible for the protrusion of leading edges, little is known about the mechanism that brings the posterior cell body forward. To elucidate the mechanism for global cell locomotion, we examined the organizational changes of filamentous (F-) actin in live Dictyostelium discoideum. We labeled F-actin with a trace amount of fluorescent phalloidin and analyzed its dynamics in nearly two-dimensional cells by using a sensitive, high-resolution charge-coupled device. We optically resolved a cyclic mode of tightening and loosening of fibrous cortical F-actin and quantitated its flow by measuring temporal and spatial intensity changes. The rate of F-actin flow was evaluated with respect to migration velocity and morphometric changes. In migrating monopodial cells, the cortical F-actin encircling the posterior cell body gradually accumulated into the tail end at a speed of 0.35 μm/minute. We show qualitatively and quantitatively that the F-actin flow is closely associated with cell migration. Similarly, in dividing cells, the cortical F-actin accumulated into the cleavage furrow. Although five times slower than the wild type, the F-actin also flows rearward in migrating mhcA− cells demonstrating that myosin II (‘conventional’ myosin) is not absolutely required for the observed dynamics of F-actin. Yet consistent with the reported transportation of ConA-beads, the direction of observed F-actin flow in Dictyostelium is conceptually opposite from a barbed-end binding to the plasma membrane. This study suggests that the posterior end of the cell has a unique motif that tugs the cortical actin layer rearward by means of a mechanism independent from myosin II; this mechanism may be also involved in cleavage furrow formation." @default.
• W2181587923 created "2016-06-24" @default.
• W2181587923 creator A5016389989 @default.
• W2181587923 creator A5035378056 @default.
• W2181587923 creator A5071321712 @default.
• W2181587923 date "1999-03-15" @default.
• W2181587923 modified "2023-09-25" @default.
• W2181587923 title "Myosin II-independent F-actin flow contributes to cell locomotion in <i>Dictyostelium</i>" @default.
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• W2181587923 doi "https://doi.org/10.1242/jcs.112.6.877" @default.
• W2181587923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10036237" @default.
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