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- W2181592013 abstract "3 Abstract: Anabolic androgenic steroids (AAS) have been associated with several side effects range from hypogonadism to cardiac and hepatic dysfunction and alteration of blood lipid levels. Artichoke leaves extract (ALE) exhibits hepatoprotective, antioxidant, hypolipidemic and hypocholesterolemic effects. The present study was conducted to evaluate for the first time whether the use of ALE in concomitant with high dose of nandrolone decanoate (ND) which is one of the AAS compounds, can improve some or most of the possible adverse effects of the drug. Fifty Wistar albino male rats were equally divided into five groups, ten each; the first group ( G1) received saline by oral gavage daily. The second group (G2) was intramuscularly injected with vehicle alone (seasam oil) once weekly. The third group (G3) received an intramuscular injection of ND (20 mg/kg) once weekly, the forth group (G4) received an oral daily dose of 1 gm /kg b.w. of ALE. The fifth group (G5) was given a combination of oral ALE in concomitant with ND the same as in G3 and G4. The duration of the experiment was 6-weeks. Blood samples were collected after two and six weeks and liver tissue samples were collected at the end of experimental period from the control and treated groups. The serum samples were assayed for glucose, lipid profile, AST, ALT, albumin, calcium and iron). Some antioxidants and oxidative stress indices (GSH, SOD, MDA and NO) were determined in the liver homogenates. Results revealed that all ND-treated animals exhibited a significant increase of body weight gain (BWG) and serum glucose, serum triacylglycerols (TAG), total cholesterol, LDL, ALT and AST and hepatic MDA content, a significant decrease in HDL and calcium, hepatic GSH content without significant change in serum albumin, iron, SOD and NO concentrations compared to control oil. On the other hand, the administration of ALE with ND could significantly modulate these abnormalities in the tested parameters. The study reflects the ameliorating effect of the ALE on the ND-induced alteration in the lipid profile, glucose level and hepatic tissues. We can conclude that ALE has antioxidative, hepatoprotective and hypolipidaemic activities that may be attributed to its constituents of polyphenolic and flavonoids." @default.
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- W2181592013 date "2012-01-01" @default.
- W2181592013 modified "2023-09-27" @default.
- W2181592013 title "Modulatory Effects of Artichock Leave Extract on Nandrolone Decanoate-Induced Biochemical Alterations in Rats" @default.
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