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• W2181637759 abstract "Background: A human neuroblastoma cell line (Paju) was induced by retinoic acid (RA) to differentiate into neuron-like cells. Materials and Methods: We studied the expression and the possible role of histamine receptors H1 and H2 retinoic-acid mediated differentiation by semiquantitative RT-PCR. We studied the effect of exogeneously added RA on the morphological change of the human neuroblastoma cell line and the differentiation was followed by vimentine, glial fibrillary acidic protein (GFAP) and neurofilament (NF) immunostaining. We monitored the change of the histidine decarboxylase (HDC) expression and the histamine content during the RA treatment by immunoblot and flow cytometry methods. Results: Our data showed that H1 and H2 histamine receptors are present on Paju cells. Ten nM RA markedly increased the H1 receptor expression of these cells, while the H2 expression was unchanged. Conclusion: In the RA-treated Paju cells, the histamine content increased compared to the untreated cells, suggesting that neuroblastoma-derived histamine is involved the regulation of RA-induced differentiation by H1 receptors . Neuroblastoma (NB) is one of the most common solid malignancies of early childhood, being derived from the neural crest (1). NB cells retain some features of neural crest progenitors, such as the ability to undergo differentiation the presence of appropriate signals. For this reason, when treated with retinoic acid (RA), human NB cells have been used as a model to study differentiation along the neuronal lineage. However, as an alternative pathway to neuronal differentiation, a flat, epithelioid or substrate-adherent phenotype has been consistently described NB cells in vitro and in vivo (2)." @default.
• W2181637759 created "2016-06-24" @default.
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• W2181637759 date "2004-05-01" @default.
• W2181637759 modified "2023-09-26" @default.
• W2181637759 title "Retinoic acid enhances histamine content and H1 receptor expression in human neuroblastoma cell line Paju." @default.
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• W2181637759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15274337" @default.
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