Matches in SemOpenAlex for { <https://semopenalex.org/work/W2181652011> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2181652011 abstract "Itisnowwidelyacceptedthathippocampalneurogenesisunderpinscriticalcognitivefunctions,suchaslearningandmemory.Toassess the behavioral importance of adult-born neurons, we developed a novel knock-in mouse model that allowed us to specifically and reversibly ablate hippocampal neurons at an immature stage. In these mice, the diphtheria toxin receptor (DTR) is expressed under control of the doublecortin (DCX) promoter, which allows for specific ablation of immature DCX-expressing neurons after administrationofdiphtheriatoxinwhileleavingtheneuralprecursorpoolintact.Usingaspatiallychallengingbehavioraltest(amodifiedversionof theactiveplaceavoidancetest),wepresentdirectevidencethatimmatureDCX-expressingneuronsarerequiredforsuccessfulacquisitionofspatiallearning,aswellasreversallearning,butarenotnecessaryfortheretrievalofstoredlong-termmemories.Importantly,the observedlearningdeficitswererescuedasnewlygeneratedimmatureneuronsrepopulatedthegranulecelllayeruponterminationofthe toxintreatment.Repeat(orcyclic)depletionofimmatureneuronsreinstatedbehavioraldeficitsifthemicewerechallengedwithanovel task.Together,thesefindingshighlightthepotentialofstimulatingneurogenesisasameanstoenhancelearning." @default.
- W2181652011 created "2016-06-24" @default.
- W2181652011 creator A5004063401 @default.
- W2181652011 creator A5026203010 @default.
- W2181652011 creator A5048260844 @default.
- W2181652011 creator A5072664985 @default.
- W2181652011 date "2013-01-01" @default.
- W2181652011 modified "2023-09-27" @default.
- W2181652011 title "ImmatureDoublecortin-PositiveHippocampalNeuronsAre ImportantforLearningButNotforRemembering" @default.
- W2181652011 cites W1963940970 @default.
- W2181652011 cites W2018793022 @default.
- W2181652011 cites W2018934769 @default.
- W2181652011 cites W2060133530 @default.
- W2181652011 cites W2076877247 @default.
- W2181652011 cites W2120811265 @default.
- W2181652011 cites W2123263640 @default.
- W2181652011 cites W2130430544 @default.
- W2181652011 cites W2131414754 @default.
- W2181652011 cites W2161423713 @default.
- W2181652011 cites W2163470859 @default.
- W2181652011 hasPublicationYear "2013" @default.
- W2181652011 type Work @default.
- W2181652011 sameAs 2181652011 @default.
- W2181652011 citedByCount "0" @default.
- W2181652011 crossrefType "journal-article" @default.
- W2181652011 hasAuthorship W2181652011A5004063401 @default.
- W2181652011 hasAuthorship W2181652011A5026203010 @default.
- W2181652011 hasAuthorship W2181652011A5048260844 @default.
- W2181652011 hasAuthorship W2181652011A5072664985 @default.
- W2181652011 hasConcept C148762608 @default.
- W2181652011 hasConcept C169760540 @default.
- W2181652011 hasConcept C2776464000 @default.
- W2181652011 hasConcept C2777367657 @default.
- W2181652011 hasConcept C2781461022 @default.
- W2181652011 hasConcept C33057221 @default.
- W2181652011 hasConcept C54355233 @default.
- W2181652011 hasConcept C86803240 @default.
- W2181652011 hasConcept C95444343 @default.
- W2181652011 hasConceptScore W2181652011C148762608 @default.
- W2181652011 hasConceptScore W2181652011C169760540 @default.
- W2181652011 hasConceptScore W2181652011C2776464000 @default.
- W2181652011 hasConceptScore W2181652011C2777367657 @default.
- W2181652011 hasConceptScore W2181652011C2781461022 @default.
- W2181652011 hasConceptScore W2181652011C33057221 @default.
- W2181652011 hasConceptScore W2181652011C54355233 @default.
- W2181652011 hasConceptScore W2181652011C86803240 @default.
- W2181652011 hasConceptScore W2181652011C95444343 @default.
- W2181652011 hasLocation W21816520111 @default.
- W2181652011 hasOpenAccess W2181652011 @default.
- W2181652011 hasPrimaryLocation W21816520111 @default.
- W2181652011 hasRelatedWork W1120595318 @default.
- W2181652011 hasRelatedWork W1990042222 @default.
- W2181652011 hasRelatedWork W1996888635 @default.
- W2181652011 hasRelatedWork W2014277329 @default.
- W2181652011 hasRelatedWork W2017830127 @default.
- W2181652011 hasRelatedWork W2078686168 @default.
- W2181652011 hasRelatedWork W2091046569 @default.
- W2181652011 hasRelatedWork W2095484189 @default.
- W2181652011 hasRelatedWork W2110164713 @default.
- W2181652011 hasRelatedWork W2112972217 @default.
- W2181652011 hasRelatedWork W2138261127 @default.
- W2181652011 hasRelatedWork W2151189924 @default.
- W2181652011 hasRelatedWork W2373408798 @default.
- W2181652011 hasRelatedWork W2523062190 @default.
- W2181652011 hasRelatedWork W2746866128 @default.
- W2181652011 hasRelatedWork W2942706388 @default.
- W2181652011 hasRelatedWork W2981538128 @default.
- W2181652011 hasRelatedWork W3035696408 @default.
- W2181652011 hasRelatedWork W3099888905 @default.
- W2181652011 hasRelatedWork W2478664523 @default.
- W2181652011 isParatext "false" @default.
- W2181652011 isRetracted "false" @default.
- W2181652011 magId "2181652011" @default.
- W2181652011 workType "article" @default.