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• W2181704066 abstract "The present study describes two French teenagers with developmental reading and writing impairments whose performance was compared to that of chronological age and read- ing age matched non-dyslexic participants. Laurent conforms to the pattern of phonological dyslexia: he exhibits a poor performance in pseudo-word reading and spelling, produces phonologically inaccurate misspellings but reads most exception words accurately. Nicolas, in contrast, is poor in reading and spelling of exception words but is quite good at pseudo- word spelling, suggesting that he suffers from surface dyslexia and dysgraphia. The two participants were submitted to an extensive battery of metaphonological tasks and to two visual attentional tasks. Laurent demonstrated poor phonemic awareness skills but good visual processing abilities, while Nicolas showed the reverse pattern with severe difficulties in the visual attentional tasks but good phonemic awareness. The present results suggest that a visual attentional disorder might be found to be associated with the pattern of developmental surface dyslexia. The present findings further show that phonological and visual processing deficits can dissociate in developmental dyslexia. Summary 3D-Quantitative structure-activity relationships of amino acid and thioxo amino acid pyrrolidides and thiazolidides as inhibitors of bacterial (F. meningosepticum) and human placenta prolyl oligopeptidase were investigated using CoMFA and COMSIA approaches. For the bacterial POP, the best CoMFA model obtained from 16 inhibitors is a five-component model with the following statistics: R 2 = 0.852 and RMSEcv = 0.213 for the cross-validation, and R 2 = 0.954 and RMSE = 0.119 for the fitted. The best COMSIA model obtained is a two-component model with the following statistics: R 2 = 0.826 and RMSEcv = 0.203 for the cross-validation, and R 2 = 0.915 and RMSE = 0.142 for the fitted. For the human placenta POP, the best CoMFA model obtained is again a five-component model. This model has the following statistics: R 2 = 0.885 and RMSEcv = 0.470 for the cross-validation, and R 2 = 0.966 and RMSE = 0.256 for the fitted. The best COMSIA model obtained is a two- component model with the following statistics: R 2 = 0.922 and RMSEcv = 0.339 for the cross-validation, and R 2 = 0.959 and RMSE = 0.247 for the fitted. A comparison of the homology models of the human and the bacterial POP reveals similarities and differences in the binding sites of the two proteins and provides some clues for the observed selectivity." @default.
• W2181704066 created "2016-06-24" @default.
• W2181704066 creator A5015182293 @default.
• W2181704066 creator A5026638037 @default.
• W2181704066 creator A5071898226 @default.
• W2181704066 creator A5072033088 @default.
• W2181704066 date "2002-01-01" @default.
• W2181704066 modified "2023-09-26" @default.
• W2181704066 title "A comparison of bacterial and human prolyl oligopeptidases: 3D-QSAR analysis of amino acid and thioxo amino acid pyrrolidides and thiazolidides as inhibitors of prolyl oligopeptidases and examination of the binding sites in the homology models of prolyl oligopeptidases" @default.
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