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- W2181740189 abstract "We present a perspective on the molecular evolution of the extracellular matrix (ECM) in metazoa that draws on researchpublications and data from sequenced genomes and expressed sequence tag libraries. ECM components do not functionin isolation, and the biological ECM system or “adhesome” also depends on posttranslational processing enzymes, cellsurface receptors, and extracellular proteases. We focus principally on the adhesome of internal tissues and discuss its originsat the dawn of the metazoa and the expansion of complexity that occurred in the chordate lineage. The analyses demonstratevery high conservation of a core adhesome that apparently evolved in a major wave of innovation in conjunction with theorigin of metazoa. Integrin, CD36, and certain domains predate the metazoa, and some ECM-related proteins are identified inchoanoflagellates as predicted sequences. Modern deuterostomes and vertebrates have many novelties and elaborations ofECM as a result of domain shuffling, domain innovations and gene family expansions. Knowledge of the evolution ofmetazoan ECM is important for understanding how it is built as a system, its roles in normal tissues and disease processes, andhas relevance for tissue engineering, the development of artificial organs, and the goals of synthetic biology.INTRODUCTION" @default.
- W2181740189 created "2016-06-24" @default.
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- W2181740189 date "2010-01-01" @default.
- W2181740189 modified "2023-09-26" @default.
- W2181740189 title "PERSPECTIVES The Evolution of Extracellular Matrix" @default.
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